Polyphenols from Alcoholic Apple Cider Are Absorbed, Metabolized and Excreted by Humans

• Published in: The Journal of nutrition Vol. 132; no. 2; pp. 172 - 175
• Main Authors: DuPont, M. Susan, Bennett, Richard N., Mellon, Fred A., Williamson, Gary
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.02.2002; American Society for Nutritional Sciences; American Institute of Nutrition
• Subjects: Absorption; Adult; Alcohol use; Alcoholic Beverages; apple cider; Apples; beverages; Biological and medical sciences; blood; caffeic acid; Caffeic Acids; Caffeic Acids - blood; Caffeic Acids - pharmacokinetics; Caffeic Acids - urine; chemistry; Chromatography, High Pressure Liquid; cider; detection limit; esters; Female; Flavonoids; Hippurates; Hippurates - blood; Hippurates - pharmacokinetics; Hippurates - urine; hippuric acid; Humans; Male; Malus; Malus - chemistry; Metabolism; Methylation; pharmacokinetics; Phenols; Phenols - blood; Phenols - metabolism; Phenols - urine; Phloretin; Phloretin - blood; Phloretin - urine; Plasma; Polymers; Polymers - metabolism; polyphenol; polyphenols; quercetin; Quercetin - blood; Quercetin - pharmacokinetics; Quercetin - urine; urine; phloretin; quercetin; flavonoids; polyphenol; cider

We determined the uptake and excretion of low doses of polyphenols in six subjects who each consumed 1.1 L of an alcoholic cider beverage. Over a 24-h period, no phloretin was detected in plasma (detection limit = 0.036 μmol/L), but 21 ± 5% of the dose (4.8 mg) was excreted in the urine. In contrast...