Adipogenic Human Adenovirus Ad‐36 Induces Commitment, Differentiation, and Lipid Accumulation in Human Adipose‐Derived Stem Cells

• Published in: Stem cells (Dayton, Ohio) Vol. 26; no. 4; pp. 969 - 978
• Main Authors: Pasarica, Magdalena, Mashtalir, Nazar, McAllister, Emily J., Kilroy, Gail E., Koska, Juraj, Permana, Paska, de Courten, Barbora, Yu, Minghuan, Ravussin, Eric, Gimble, Jeffery M., Dhurandhar, Nikhil V.
• Format: Journal Article
• Language: English
• Published: Bristol John Wiley & Sons, Ltd 01.04.2008
• Subjects: Adenoviruses, Human - physiology; Adipocyte progenitors; Adipocytes - cytology; Adipocytes - physiology; Adipocytes - virology; Adipogenesis; Adipogenesis - physiology; Adipose Tissue - cytology; Adipose Tissue - physiology; Adipose Tissue - virology; Adiposity; Adult; Cell Differentiation - physiology; Cells, Cultured; Female; Human adenovirus; Humans; Infectobesity; Lipid Metabolism - physiology; Lipids - physiology; Lipogenesis; Male; Middle Aged; Obesity; Stem Cells - cytology; Stem Cells - physiology; Stem Cells - virology

Human adenovirus Ad‐36 is causatively and correlatively linked with animal and human obesity, respectively. Ad‐36 enhances differentiation of rodent preadipocytes, but its effect on adipogenesis in humans is unknown. To indirectly assess the role of Ad‐36‐induced adipogenesis in human obesity, the e...