Driving the Hypoxia-Inducible Pathway in Human Pericytes Promotes Vascular Density in an Exosome-Dependent Manner

• Published in: Microcirculation (New York, N.Y. 1994) Vol. 22; no. 8; pp. 711 - 723
• Main Authors: Mayo, Jamie N., Bearden, Shawn E.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2015; Wiley Subscription Services, Inc
• Subjects: angiogenesis; Capillaries - cytology; Capillaries - metabolism; Cell Hypoxia; endothelium; exosomes; Exosomes - metabolism; Humans; hypoxia-inducible factor; Neovascularization, Physiologic; pericytes; Pericytes - cytology; Pericytes - metabolism; spinal cord; endothelium; hypoxia-inducible factor; spinal cord; angiogenesis; exosomes; pericytes

Objectives The mechanisms involved in activating pericytes, cells that ensheath capillaries, to engage in the formation of new capillaries, angiogenesis, remain unknown. In this study, the hypothesis was tested that pericytes could be stimulated to promote angiogenesis by driving the HIF pathway. Me...