Longitudinal Trends of Prevalence of Neutralizing Antibody against Human Cytomegalovirus over the Past 30 Years in Japanese Women

• Published in: Japanese Journal of Infectious Diseases Vol. 75; no. 5; pp. 496 - 503
• Main Authors: Shibamura, Miho, Yamada, Souichi, Yoshikawa, Tomoki, Inagaki, Takuya, Nguyen, Phu Hoang Anh, Fujii, Hikaru, Harada, Shizuko, Fukushi, Shuetsu, Oka, Akira, Mizuguchi, Masashi, Saijo, Masayuki
• Format: Journal Article
• Language: English
• Published: Tokyo National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee 30.09.2022; Japan Science and Technology Agency
• Subjects: Antibodies; congenital cytomegalovirus infection; Cytomegalovirus; Enzyme immunoassay; Epithelial cells; Epithelium; Fetuses; human cytomegalovirus; Immunoassay; Immunofluorescence; Immunoglobulin G; Japan; Neutralization; Neutralizing; neutralizing antibody; Pregnancy; Risk; seroprevalence

Neutralizing antibodies (NAbs) to human cytomegalovirus (HCMV) are associated with the risk of transplacental HCMV infection of the fetus in pregnant women. The IgG-positivity rate to HCMV determined by enzyme immunoassay (EIA) or indirect immunofluorescence assay has decreased from approximately 10...