Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

• Published in: The Journal of physiology Vol. 590; no. 14; pp. 3349 - 3360
• Main Authors: Larsen, Steen, Nielsen, Joachim, Hansen, Christina Neigaard, Nielsen, Lars Bo, Wibrand, Flemming, Stride, Nis, Schroder, Henrik Daa, Boushel, Robert, Helge, Jørn Wulff, Dela, Flemming, Hey‐Mogensen, Martin
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2012; Wiley Subscription Services, Inc; Blackwell Science Inc
• Subjects: Adenosine Triphosphatases - analysis; Adult; Biomarkers; Biomarkers - analysis; Cardiolipins - analysis; Carrier Proteins - analysis; Citrate (si)-Synthase - analysis; Electron Transport Complex I - analysis; Exercise Test; Humans; Male; Membrane Proteins - analysis; Microscopy, Electron, Transmission; Mitochondria, Muscle - chemistry; Mitochondria, Muscle - ultrastructure; Mitochondrial DNA; Muscle Fibers, Skeletal - chemistry; Muscle Fibers, Skeletal - ultrastructure; Musculoskeletal system; Oxidative Phosphorylation; Oxygen Consumption; Quadriceps Muscle - chemistry; Quadriceps Muscle - cytology; Respiration; Skeletal Muscle and Exercise; Transmission electron microscopy

Key points •  Several biochemical measures of mitochondrial components are used as biomarkers of mitochondrial content and muscle oxidative capacity. However, no studies have validated these surrogates against a morphological measure of mitochondrial content in human subjects. •  The most commonly u...