Effect of Opioid on Adult Hippocampal Neurogenesis

During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid. He...

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Published inTheScientificWorld Vol. 2016; no. 2016; pp. 1 - 7
Main Authors Zhang, Yue, Law, Ping-Yee, Loh, Horace H.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2016
John Wiley & Sons, Inc
Wiley
Subjects
Aging - physiology
Analgesics
Analgesics, Opioid - pharmacology
Animals
Antigens
Apoptosis - drug effects
Brain
Cell adhesion & migration
Cell cycle
Developmental stages
Dosage and administration
Drug abuse
Drugs
Health aspects
Hippocampus (Brain)
Hippocampus - drug effects
Hippocampus - physiology
Humans
Kinases
Narcotics
Neural Stem Cells - cytology
Neural Stem Cells - drug effects
Neurogenesis
Neurogenesis - drug effects
Opioids
Patient outcomes
Proteins
Review
Rodents
Studies
Vascular endothelial growth factor
Online AccessGet full text

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Abstract During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid. Here, we review the most recent works on opiate drugs’ effect on different developmental stages of adult hippocampal neurogenesis, as well as the possible underlying mechanisms. We conclude that opiate drugs in general cause a loss of newly born neural progenitors in the subgranular zone of dentate gyrus, by either modulating proliferation or interfering with differentiation and maturation. We also discuss the consequent impact of regulation of adult neurogenesis in animal’s opioid addiction behavior. We further look into the future directions in studying the convergence between the adult neurogenesis field and opioid addiction field, since the adult-born granular cells were shown to play a role in neuroplasticity and may help to reduce the vulnerability to drug craving and relapse.
AbstractList During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid. Here, we review the most recent works on opiate drugs’ effect on different developmental stages of adult hippocampal neurogenesis, as well as the possible underlying mechanisms. We conclude that opiate drugs in general cause a loss of newly born neural progenitors in the subgranular zone of dentate gyrus, by either modulating proliferation or interfering with differentiation and maturation. We also discuss the consequent impact of regulation of adult neurogenesis in animal’s opioid addiction behavior. We further look into the future directions in studying the convergence between the adult neurogenesis field and opioid addiction field, since the adult-born granular cells were shown to play a role in neuroplasticity and may help to reduce the vulnerability to drug craving and relapse.
During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid. Here, we review the most recent works on opiate drugs' effect on different developmental stages of adult hippocampal neurogenesis, as well as the possible underlying mechanisms. We conclude that opiate drugs in general cause a loss of newly born neural progenitors in the subgranular zone of dentate gyrus, by either modulating proliferation or interfering with differentiation and maturation. We also discuss the consequent impact of regulation of adult neurogenesis in animal's opioid addiction behavior. We further look into the future directions in studying the convergence between the adult neurogenesis field and opioid addiction field, since the adult-born granular cells were shown to play a role in neuroplasticity and may help to reduce the vulnerability to drug craving and relapse.During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid. Here, we review the most recent works on opiate drugs' effect on different developmental stages of adult hippocampal neurogenesis, as well as the possible underlying mechanisms. We conclude that opiate drugs in general cause a loss of newly born neural progenitors in the subgranular zone of dentate gyrus, by either modulating proliferation or interfering with differentiation and maturation. We also discuss the consequent impact of regulation of adult neurogenesis in animal's opioid addiction behavior. We further look into the future directions in studying the convergence between the adult neurogenesis field and opioid addiction field, since the adult-born granular cells were shown to play a role in neuroplasticity and may help to reduce the vulnerability to drug craving and relapse.
Audience Academic
Author Law, Ping-Yee
Zhang, Yue
Loh, Horace H.
AuthorAffiliation Department of Pharmacology, University of Minnesota, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455-0217, USA
AuthorAffiliation_xml – name: Department of Pharmacology, University of Minnesota, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455-0217, USA
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/27127799$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright Copyright © 2016 Yue Zhang et al.
COPYRIGHT 2016 John Wiley & Sons, Inc.
Copyright © 2016 Yue Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2016 Yue Zhang et al. 2016
Copyright_xml – notice: Copyright © 2016 Yue Zhang et al.
– notice: COPYRIGHT 2016 John Wiley & Sons, Inc.
– notice: Copyright © 2016 Yue Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2016 Yue Zhang et al. 2016
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Snippet During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the...
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SubjectTerms Aging - physiology
Analgesics
Analgesics, Opioid - pharmacology
Animals
Antigens
Apoptosis - drug effects
Brain
Cell adhesion & migration
Cell cycle
Developmental stages
Dosage and administration
Drug abuse
Drugs
Health aspects
Hippocampus (Brain)
Hippocampus - drug effects
Hippocampus - physiology
Humans
Kinases
Narcotics
Neural Stem Cells - cytology
Neural Stem Cells - drug effects
Neurogenesis
Neurogenesis - drug effects
Opioids
Patient outcomes
Proteins
Review
Rodents
Studies
Vascular endothelial growth factor
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Title Effect of Opioid on Adult Hippocampal Neurogenesis
URI https://search.emarefa.net/detail/BIM-1120354
https://dx.doi.org/10.1155/2016/2601264
https://www.ncbi.nlm.nih.gov/pubmed/27127799
https://www.proquest.com/docview/1781482891
https://www.proquest.com/docview/1785736592
https://www.proquest.com/docview/1805495814
https://pubmed.ncbi.nlm.nih.gov/PMC4835638
https://doaj.org/article/6b82881c9c6b45189db6a35020aaea0c
Volume 2016
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