Can selenium‐enriched spirulina supplementation ameliorate sepsis outcomes in selenium‐deficient animals?

• Published in: Physiological reports Vol. 9; no. 14; pp. e14933 - n/a
• Main Authors: Castel, Thomas, Theron, Michaël, Pichavant‐Rafini, Karine, Guernec, Anthony, Joublin‐Delavat, Aurélie, Gueguen, Bleuenn, Leon, Karelle
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.07.2021; Wiley; John Wiley and Sons Inc
• Subjects: Acidosis; Algae; Animals; Antioxidants; Antioxidants - administration & dosage; Catheters; Cecum; Cytokines; Dietary Supplements; Drinking water; Ethics; Experiments; Female; GPx; Inflammation; Inflammation Mediators - antagonists & inhibitors; Inflammation Mediators - blood; Intensive care; Intensive care units; lactates; Laparotomy; Life Sciences; Mortality; mRNA; Original; Oxidative stress; Plasma; Rats; Rats, Wistar; Selenium; Selenium - administration & dosage; Selenium - blood; Selenium - deficiency; Sepsis; Sepsis - blood; Sepsis - therapy; Sodium selenite; Spirulina; supplementation; Survival; Tumor necrosis factor; Tumor necrosis factor-TNF; supplementation; Spirulina; selenium; lactates; GPx; sepsis
• ISSN: 2051-817X; 2051-817X
• DOI: 10.14814/phy2.14933

In intensive care units, sepsis is the first cause of death. In this pathology, inflammation and oxidative status play a crucial role in patient outcomes. Interestingly, 92% of septic patients exhibit low selenium plasma concentrations (a component of antioxidant enzymes). Moreover, Spirulina platen...