Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity

• Published in: Immunological reviews Vol. 251; no. 1; pp. 160 - 176
• Main Authors: Malhotra, Deepali, Fletcher, Anne L., Turley, Shannon J.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.01.2013
• Subjects: Adaptive Immunity; Animals; Antigen Presentation; Antigen-presenting cells; blood endothelial cell; CD8 antigen; Cell Communication - immunology; Cell interactions; Cell migration; Cell Movement - immunology; Chemokines; Chemokines - immunology; dendritic cell; Dendritic cells; fibroblastic reticular cell; Hematopoietic Stem Cells - immunology; Hemopoiesis; Humans; Immune response; Immunity; Immunological tolerance; Inflammation; integrin α7+ pericyte; Lymph nodes; Lymph Nodes - immunology; lymphatic endothelial cell; Lymphocyte Activation; Lymphocytes T; Parenchyma; Peyer's patches; scaffolds; Spleen; stromal cells; Stromal Cells - immunology; T cell; tolerance/suppression

Summary Secondary lymphoid organs (SLOs), including lymph nodes, Peyer's patches, and the spleen, have evolved to bring cells of the immune system together. In these collaborative environments, lymphocytes scan the surfaces of antigen‐presenting cells for cognate antigens, while moving along st...