Analysis of HCRTR2 Gene Variants and Cluster Headache in Sweden

• Published in: Headache Vol. 59; no. 3; pp. 410 - 417
• Main Authors: Fourier, Carmen, Ran, Caroline, Steinberg, Anna, Sjöstrand, Christina, Waldenlind, Elisabet, Belin, Andrea Carmine
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2019; John Wiley and Sons Inc
• Subjects: Alleles; case‐control study; Circadian rhythms; Clusters; Gene frequency; Gene polymorphism; haplotype; Haplotypes; Headache; Headaches; Hypothalamus; Migraine; Orexin receptors; Orexins; Patients; Permutations; Polymorphism; Population (statistical); Population genetics; Research Submission; Research Submissions; Single-nucleotide polymorphism; Statistical analysis; Studies; case-control study; polymorphism; haplotype

Objective The purpose of this study was to investigate the HCRTR2 gene variants rs3122156, rs2653342, and rs2653349 in a large homogenous Swedish case‐control cohort in order to further evaluate the possible contribution of HCRTR2 to cluster headache. Background Cluster headache is a severe neurovas...