Continuous Oral Administration of the Superantigen Staphylococcal Enterotoxin C2 Activates Intestinal Immunity and Modulates the Gut Microbiota in Mice

• Published in: Advanced science Vol. 11; no. 41; pp. e2405039 - n/a
• Main Authors: Gu, Wu, Zhang, Huiwen, Zhang, Zhichun, Xu, Mingkai, Li, Xiang, Han, Zhiyang, Fu, Xuanhe, Li, Xu, Wang, Xiujuan, Zhang, Chenggang
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.11.2024; John Wiley and Sons Inc; Wiley
• Subjects: Administration, Oral; Animals; Antigens; Cytokines; Defecation; Drug dosages; Enterotoxins - administration & dosage; Enterotoxins - immunology; Female; Gastrointestinal Microbiome - drug effects; Gastrointestinal Microbiome - immunology; gut microbiota; Homeostasis; Immune system; Immunity (Disease); Immunoglobulins; intestinal barrier; intestinal immune; Lymphatic system; Lymphocytes; Mice; Mice, Inbred BALB C; Microbiota; Oral administration; SEC2; Small intestine; superantigen; Superantigens - immunology; Toxicity; Tumor necrosis factor-TNF; Tumors; oral administration; superantigen; intestinal barrier; intestinal immune; gut microbiota; SEC2

Staphylococcal Enterotoxin C2 (SEC2), a classical superantigen, is an antitumor immunotherapy agent. However, the injectable formulation of SEC2 limits its clinical application. Here, it is reported that oral administration of SEC2 activates the intestinal immune system and benefits intestinal healt...