Hedgehog‐EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour‐initiating pancreatic cancer cells

• Published in: EMBO molecular medicine Vol. 4; no. 3; pp. 218 - 233
• Main Authors: Eberl, Markus, Klingler, Stefan, Mangelberger, Doris, Loipetzberger, Andrea, Damhofer, Helene, Zoidl, Kerstin, Schnidar, Harald, Hache, Hendrik, Bauer, Hans‐Christian, Solca, Flavio, Hauser‐Kronberger, Cornelia, Ermilov, Alexandre N., Verhaegen, Monique E., Bichakjian, Christopher K., Dlugosz, Andrzej A., Nietfeld, Wilfried, Sibilia, Maria, Lehrach, Hans, Wierling, Christoph, Aberger, Fritz
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2012; WILEY‐VCH Verlag; EMBO Press; WILEY-VCH Verlag
• Subjects: Animal models; Animals; Basal cell carcinoma; Binding sites; cancer; Carcinoma, Basal Cell - genetics; Carcinoma, Basal Cell - metabolism; Carcinoma, Basal Cell - pathology; Cell Line, Tumor; Cell proliferation; Cooperation; Cooperativity; CXCR4 protein; Drug resistance; Epidermal growth factor; epidermal growth factor receptor; Epidermal growth factor receptors; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Gene expression; Gene Expression Regulation, Neoplastic; Genetic transformation; Hedgehog protein; Hedgehog Proteins - genetics; Hedgehog Proteins - metabolism; Hedgehog signalling; Humans; Integration; Melanoma; Metastasis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis; Pancreatic cancer; Pancreatic carcinoma; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Phenotype; Phenotypes; Receptor, Epidermal Growth Factor - genetics; Receptor, Epidermal Growth Factor - metabolism; Receptors, CXCR4 - genetics; Receptors, CXCR4 - metabolism; Research Article; Signal transduction; Skin cancer; Sox9 protein; SOX9 Transcription Factor - genetics; SOX9 Transcription Factor - metabolism; SOXB1 Transcription Factors - genetics; SOXB1 Transcription Factors - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Tumor Burden; Tumors; Zinc Finger Protein GLI1; cancer; Hedgehog signalling; signal transduction; epidermal growth factor receptor

Inhibition of Hedgehog (HH)/GLI signalling in cancer is a promising therapeutic approach. Interactions between HH/GLI and other oncogenic pathways affect the strength and tumourigenicity of HH/GLI. Cooperation of HH/GLI with epidermal growth factor receptor (EGFR) signalling promotes transformation...