Porins of Pseudomonas aeruginosa induce release of tumor necrosis factor alpha and interleukin-6 by human leukocytes

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Published inInfection and Immunity Vol. 65; no. 5; pp. 1683 - 1687
Main Authors CUSUMANO, V, TUFANO, M. A, MANCUSO, G, CARBONE, M, ROSSANO, F, FERA, M. T, CILIBERTI, F. A, RUOCCO, E, ALBA MERENDINO, R, TETI, G
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.05.1997
Subjects
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Bacterial Toxins - isolation & purification
Bacterial Toxins - pharmacology
Bacteriology
Biological and medical sciences
Cells, Cultured
Electrophoresis, Polyacrylamide Gel
Fundamental and applied biological sciences. Psychology
Glycosaminoglycans - isolation & purification
Glycosaminoglycans - pharmacology
Granulocytes - immunology
Granulocytes - metabolism
Humans
Interleukin-6 - metabolism
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Kinetics
Leukocytes, Mononuclear - metabolism
Leukocytes, Mononuclear - microbiology
Lipopolysaccharides - isolation & purification
Lipopolysaccharides - pharmacology
Microbiology
Monocytes - immunology
Monocytes - metabolism
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Porins - isolation & purification
Porins - pharmacology
Pseudomonas aeruginosa
Pseudomonas aeruginosa - chemistry
Pseudomonas aeruginosa - immunology
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Tumor Necrosis Factor-alpha - metabolism
Pseudomonadales
Human
Porin
Induction
Leukocyte
Cytokine
Host agent relation
In vitro
Biological activity
Interleukin 6
Bacteria
Pseudomonadaceae
Pseudomonas aeruginosa
Tumor necrosis factor α
Release
Online AccessGet full text

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AbstractList The aim of this study was to examine the ability of Pseudomonas aeruginosa components to induce release of cytokines from human leukocytes. Human whole-blood cultures were incubated with several concentrations of purified P. aeruginosa products, including porins, exomucopolysaccharide, lipopolysaccharide, and toxin A. Supernatants were assayed for tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) activities. All of the P. aeruginosa components except toxin A were able to stimulate the release of both cytokines. On a weight basis, porins were as effective as lipopolysaccharide and significantly more effective than exomucopolysaccharide in inducing IL-6 release (P < 0.05). Moreover, porins were more potent than either exomucopolysaccharide or lipopolysaccharide in inducing TNF-alpha release (P < 0.05). Further experiments using isolated leukocytes suggested that monocytes were the cell population predominantly responsible for the production of both cytokines. These data indicate that P. aeruginosa porins are able to induce significant cytokine production. These components may be responsible for the chronically overactive inflammatory response associated with persistent lung infection in cystic fibrosis patients.
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The aim of this study was to examine the ability of Pseudomonas aeruginosa components to induce release of cytokines from human leukocytes. Human whole-blood cultures were incubated with several concentrations of purified P. aeruginosa products, including porins, exomucopolysaccharide, lipopolysaccharide, and toxin A. Supernatants were assayed for tumor necrosis factor alpha (TNF- alpha ) and interleukin-6 (IL-6) activities. All of the P. aeruginosa components except toxin A were able to stimulate the release of both cytokines. On a weight basis, porins were as effective as lipopolysaccharide and significantly more effective than exomucopolysaccharide in inducing IL-6 release. Moreover, porins were more potent than either exomucopolysaccharide or lipopolysaccharide in inducing TNF- alpha release. Further experiments using isolated leukocytes suggested that monocytes were the cell population predominantly responsible for the production of both cytokines. These data indicate that P. aeruginosa porins are able to induce significant cytokine production. These components may be responsible for the chronically overactive inflammatory response associated with persistent lung infection in cystic fibrosis patients.
Author M T Fera
V Cusumano
M Carbone
F Rossano
E Ruocco
F A Ciliberti
R A Merendino
G Mancuso
G Teti
M A Tufano
AuthorAffiliation Istituto di Microbiologia, Facolta di Medicina e Chirurgia, Universita degli Studi di Messina, Italy
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Issue 5
Keywords Pseudomonadales
Human
Porin
Induction
Leukocyte
Cytokine
Host agent relation
In vitro
Biological activity
Interleukin 6
Bacteria
Pseudomonadaceae
Pseudomonas aeruginosa
Tumor necrosis factor α
Release
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Snippet Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon...
The aim of this study was to examine the ability of Pseudomonas aeruginosa components to induce release of cytokines from human leukocytes. Human whole-blood...
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SubjectTerms B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Bacterial Toxins - isolation & purification
Bacterial Toxins - pharmacology
Bacteriology
Biological and medical sciences
Cells, Cultured
Electrophoresis, Polyacrylamide Gel
Fundamental and applied biological sciences. Psychology
Glycosaminoglycans - isolation & purification
Glycosaminoglycans - pharmacology
Granulocytes - immunology
Granulocytes - metabolism
Humans
Interleukin-6 - metabolism
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Kinetics
Leukocytes, Mononuclear - metabolism
Leukocytes, Mononuclear - microbiology
Lipopolysaccharides - isolation & purification
Lipopolysaccharides - pharmacology
Microbiology
Monocytes - immunology
Monocytes - metabolism
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Porins - isolation & purification
Porins - pharmacology
Pseudomonas aeruginosa
Pseudomonas aeruginosa - chemistry
Pseudomonas aeruginosa - immunology
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Tumor Necrosis Factor-alpha - metabolism
Title Porins of Pseudomonas aeruginosa induce release of tumor necrosis factor alpha and interleukin-6 by human leukocytes
URI http://iai.asm.org/content/65/5/1683.abstract
https://www.ncbi.nlm.nih.gov/pubmed/9125547
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Volume 65
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