Molecular Screening via Sanger Sequencing of the Genetic Variants in Non-Alcoholic Fatty Liver Disease Subjects in the Saudi Population: A Hospital-Based Study

• Published in: Metabolites Vol. 12; no. 12; p. 1240
• Main Authors: Alsaif, Faisal, Al-hamoudi, Waleed, Alotaiby, Maram, Alsadoon, Amani, Almayouf, Mohammed, Almadany, Hadeel, Abuhaimed, Jawahir, Ghufran, Noman, Merajuddin, Ahmed, Ali Khan, Imran
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2022; MDPI
• Subjects: Biopsy; Body mass index; Chi-square test; Cirrhosis; Diabetes; DNA sequencing; Fatty liver; Gene polymorphism; Genes; Genetic diversity; Genome-wide association studies; Health risk assessment; Hepatitis; Hepatocellular carcinoma; HFE; Inflammation; Insulin resistance; Liver cancer; Liver cirrhosis; Liver diseases; Medical research; Medicine, Experimental; Metabolic disorders; NAFLD; NASH; non-NAFLD; Nucleotide sequencing; Obesity; Overweight; PNPLA3; Population studies; Software; Steatosis; TM6SF2; Saudi Arabia; non-NAFLD; Saudi population; NAFLD; HFE; PNPLA3; NASH; TM6SF2

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, along with steatosis and non-alcoholic steatohepatitis (NASH), and is associated with cirrhosis and hepatocellular carcinoma. Candidate gene and genome-wide association studies have validated the relationships betwee...