Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells

• Published in: Cell Vol. 139; no. 7; pp. 1303 - 1314
• Main Authors: Shen, Xiaohua, Kim, Woojin, Fujiwara, Yuko, Simon, Matthew D., Liu, Yingchun, Mysliwiec, Matthew R., Yuan, Guo-Cheng, Lee, Youngsook, Orkin, Stuart H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.12.2009
• Subjects: Animals; Cell Differentiation; Chromatin Assembly and Disassembly; DEVBIO; Embryonic Stem Cells - cytology; HeLa Cells; Histone-Lysine N-Methyltransferase - metabolism; Histones - metabolism; Humans; Mice; Nerve Tissue Proteins - metabolism; Polycomb Repressive Complex 2; Polycomb-Group Proteins; PROTEINS; Repressor Proteins - metabolism; STEMCELL; STEMCELL; PROTEINS; DEVBIO

Trimethylation on histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2 (PRC2) regulates the balance between self-renewal and differentiation of embryonic stem cells (ESCs). The mechanisms controlling the activity and recruitment of PRC2 are largely unknown. Here we demonstrate that the f...