Loss of fragile WWOX gene leads to senescence escape and genome instability - Cheng, Hui-Ching; Huang, Po-Hsien; Lai, Feng-Jie; Jan, Ming-Shiou; Chen, Yi-Lin; Chen, Szu-Ying; Chen, Wan-Li; Hsu, Chao-Kai; Huang, Wenya; Hsu, Li-Jin (Cellular and molecular life sciences : CMLS, 2023)
Keywords: Acetylcysteine; Anomalies; Apoptosis; Biochemistry; Biodegradation; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell culture; Cell cycle; Cell proliferation; cell senescence; Chromosomes; Cyclin-dependent kinase; Cyclin-dependent kinase inhibitor p21; Cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitors; Cyclin-dependent kinases; Damage; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA damage; DNA replication; DNA-binding domains; Embryo fibroblasts; Fibroblasts; genes; genetic instability; Genomes; Genomic instability; GTP-binding protein; humans; INK4a protein; Integrity; Kinases; Life Sciences; loss-of-function mutation; Metaphase; mice; Microsatellite instability; microsatellite repeats; mitosis; nuclear genome; Original; Original Article; Oxidative stress; p16 Protein; p53 Protein; protein degradation; Proteins; Radiation effects; Reactive oxygen species; Replication; Senescence; Ultraviolet radiation; Promoter hypermethylation; CDK inhibitors; Tumor suppressor; Replicative arrest; Mononucleotide repeat markers; Redox homeostasis