Variant Aldehyde Dehydrogenase 2 (ALDH22) in East Asians Interactively Exacerbates Tobacco Smoking Risk for Coronary Spasm　― Possible Role of Reactive Aldehydes

• Published in: Circulation Journal Vol. 81; no. 1; pp. 96 - 102
• Main Authors: Mizuno, Yuji, Harada, Eisaku, Kinoshita, Kenji, Yoshimura, Michihiro, Hokimoto, Seiji, Yasue, Hirofumi
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 01.01.2017
• Subjects: Aged; Aldehyde dehydrogenase 2; Aldehyde Dehydrogenase, Mitochondrial - genetics; Aldehyde Dehydrogenase, Mitochondrial - metabolism; Aldehydes - blood; Angina Pectoris - blood; Angina Pectoris - enzymology; Angina Pectoris - etiology; Angina Pectoris - genetics; Asian People; Cholesterol, HDL - blood; Coronary spastic angina; Coronary Vasospasm - blood; Coronary Vasospasm - enzymology; Coronary Vasospasm - etiology; Coronary Vasospasm - genetics; East Asians; Female; Genotype; Humans; Japan; Male; Middle Aged; Reactive aldehydes; Sex Factors; Smoking - adverse effects; Smoking - blood; Smoking - genetics; Tobacco smoking; Uric Acid - blood; Japan

Background:Coronary spastic angina (CSA) is common among East Asians and tobacco smoking (TS) is an established risk factor for CSA. Aldehyde dehydrogenase 2 (ALDH2) plays a key role in removing reactive toxic aldehydes and a deficient variant ALDH2 genotype (ALDH2*2) is prevalent among East Asians....