Der p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus - Herman, Julie; Thelen, Nicolas; Smargiasso, Nicolas; Mailleux, Anne-Catherine; Luxen, André; Cloes, Marie; De Pauw, Edwin; Chevigné, Andy; Galleni, Moreno; Dumez, Marie-Eve (Biochimica et biophysica acta, 2014)
Keywords: Allergens; Allergens - metabolism; AMC; AMg; Amino Acid Sequence; Animals; Antigens, Dermatophagoides; Antigens, Dermatophagoides - analysis; Antigens, Dermatophagoides - metabolism; Arthropod Proteins; Arthropod Proteins - analysis; Arthropod Proteins - metabolism; Biochemistry, biophysics & molecular biology; Biochimie, biophysique & biologie moléculaire; cysteine; Cysteine Endopeptidases; Cysteine Endopeptidases - analysis; Cysteine Endopeptidases - metabolism; DAPI; Dermatophagoides pteronyssinus; Dermatophagoides pteronyssinus - immunology; Digestion; dust; dust mites; E-64; energy transfer; Enzyme Activation; enzyme activity; enzyme inhibition; Enzyme Precursors; Enzyme Precursors - metabolism; Forster resonance energy transfer; FRET; Förster Resonance Energy Transfer; HDM(e); hypersensitivity; Komagataella pastoris; Life sciences; midgut; Mite allergen; Molecular Sequence Data; pathogenesis; peptides; Pichia pastoris; PMg; Protease; proteinases; Proteolysis; Recombinant Proteins; Recombinant Proteins - metabolism; SBTI; Sciences du vivant; serine; Serine Endopeptidases; Serine Endopeptidases - analysis; Serine Endopeptidases - metabolism; zymogens; SBTI; Mite allergen; HDM(e); E-64; DAPI; pDp6; FP; PMg; Digestion; Dermatophagoides pteronyssinus; nDer p 6; Protease; AMC; rDer p 6; FRET; AMg; rDer p 1; Hg; Förster Resonance Energy Transfer; natural Der p 6; recombinant Der p 1; hindgut; 7-amido-4-methylcoumarin; proDer p 6; recombinant Der p 6; 4′,6-DiAmidino-2-PhenylIndole; anterior midgut; posterior midgut; soybean trypsin inhibitor; house dust mite (extracts); l-trans-epoxysuccinyl-leucylamido (4-guanidino) butane; faecal pellet