Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth

• Published in: Immunity (Cambridge, Mass.) Vol. 45; no. 5; pp. 1108 - 1121
• Main Authors: Huang, Jinghe, Kang, Byong H., Ishida, Elise, Zhou, Tongqing, Griesman, Trevor, Sheng, Zizhang, Wu, Fan, Doria-Rose, Nicole A., Zhang, Baoshan, McKee, Krisha, O’Dell, Sijy, Chuang, Gwo-Yu, Druz, Aliaksandr, Georgiev, Ivelin S., Schramm, Chaim A., Zheng, Anqi, Joyce, M. Gordon, Asokan, Mangaiarkarasi, Ransier, Amy, Darko, Sam, Migueles, Stephen A., Bailer, Robert T., Louder, Mark K., Alam, S. Munir, Parks, Robert, Kelsoe, Garnett, Von Holle, Tarra, Haynes, Barton F., Douek, Daniel C., Hirsch, Vanessa, Seaman, Michael S., Shapiro, Lawrence, Mascola, John R., Kwong, Peter D., Connors, Mark
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.11.2016; Elsevier Limited
• Subjects: 60 APPLIED LIFE SCIENCES; Antibodies, Neutralizing - immunology; antibody; Antibody Specificity; BASIC BIOLOGICAL SCIENCES; Binding sites; Binding Sites, Antibody - immunology; Bioinformatics; CD4-binding site; CD4-Positive T-Lymphocytes - immunology; Cell Separation; Cloning; envelope; Glycoproteins; HIV; HIV Antibodies - immunology; HIV Envelope Protein gp120 - immunology; HIV Infections - immunology; HIV-1 - immunology; Humans; Immunoglobulins; Immunotherapy; Light; neutralizing; Patients; Phylogenetics; Plasmids; prophylaxis; Proteins; resistance; structure; vaccine; Vaccines; Viruses; vaccine; envelope; antibody; HIV; immunotherapy; neutralizing; CD4-binding site; prophylaxis; resistance; structure

Detailed studies of the broadly neutralizing antibodies (bNAbs) that underlie the best available examples of the humoral immune response to HIV are providing important information for the development of therapies and prophylaxis for HIV-1 infection. Here, we report a CD4-binding site (CD4bs) antibod...