Increased neutrophil respiratory burst in bcr-null mutants
Philadelphia (Ph)-positive leukemias invariably contain a chromosomal translocation fusing BCR to ABL. The BCR-ABL protein is responsible for leukemogenesis. Here we show that exposure of bcr-null mutant mice to gram-negative endotoxin led to severe septic shock and increased tissue injury by neutro...
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| Published in | Cell Vol. 80; no. 5; pp. 719 - 728 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
10.03.1995
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Philadelphia (Ph)-positive leukemias invariably contain a chromosomal translocation fusing
BCR to
ABL. The BCR-ABL protein is responsible for leukemogenesis. Here we show that exposure of
bcr-null mutant mice to gram-negative endotoxin led to severe septic shock and increased tissue injury by neutrophils. Neutrophils of
bcr (-/-) mice showed a pronounced increase in reactive oxygen metabolite production upon activation and were more sensitive to priming stimuli. Activated (-/-) neutrophils displayed a 3-fold increased p21
rac2
membrane translocation compared with (+/+) neutrophils. These results connect Bcr in vivo with the regulation of Rac-mediated superoxide production by the NADPH-oxidase system of leukocytes and suggest a link between Bcr function and the cell type affected in Ph-positive leukemia. |
|---|---|
| AbstractList | Philadelphia (Ph)-positive leukemias invariably contain a chromosomal translocation fusing
BCR to
ABL. The BCR-ABL protein is responsible for leukemogenesis. Here we show that exposure of
bcr-null mutant mice to gram-negative endotoxin led to severe septic shock and increased tissue injury by neutrophils. Neutrophils of
bcr (-/-) mice showed a pronounced increase in reactive oxygen metabolite production upon activation and were more sensitive to priming stimuli. Activated (-/-) neutrophils displayed a 3-fold increased p21
rac2
membrane translocation compared with (+/+) neutrophils. These results connect Bcr in vivo with the regulation of Rac-mediated superoxide production by the NADPH-oxidase system of leukocytes and suggest a link between Bcr function and the cell type affected in Ph-positive leukemia. Philadelphia (Ph)-positive leukemias invariably contain a chromosomal translocation fusing BCR to ABL. The BCR-ABL protein is responsible for leukemogenesis. Here we show that exposure of bcr-null mutant mice to gram-negative endotoxin led to severe septic shock and increased tissue injury by neutrophils. Neutrophils of bcr (-/-) mice showed a pronounced increase in reactive oxygen metabolite production upon activation and were more sensitive to priming stimuli. Activated (-/-) neutrophils displayed a 3-fold increased p21rac2 membrane translocation compared with (+/+) neutrophils. These results connect Bcr in vivo with the regulation of Rac-mediated superoxide production by the NADPH-oxidase system of leukocytes and suggest a link between Bcr function and the cell type affected in Ph-positive leukemia. Philadelphia (Ph)-positive leukemias invariably contain a chromosomal translocation fusing BCR to ABL. The BCR-ABL protein is responsible for leukemogenesis. Here we show that exposure of bcr-null mutant mice to gram-negative endotoxin led to severe septic shock and increased tissue injury by neutrophils. Neutrophils of bcr (-l-) mice showed a pronounced increase in reactive oxygen metabolite production upon activation and were more sensitive to priming stimuli. Activated (-l-) neutrophils displayed a 3-fold increased p21 super(rac2) membrane translocation compared with (+/+) neutrophils. These results connect Bcr in vivo with the regulation of Rac-mediated superoxide production by the NADPH-oxidase system of leukocytes and suggest a link between Bcr function and the cell type affected in Ph-positive leukemia. |
| Author | Heisterkamp, Nora Bokoch, Gary M Kaartinen, Vesa Schaick, Hermien van Coates, Thomas Dorseuil, Olivier Landing, Benjamin Pattengale, Paul Voncken, Jan Willem Deemer, Kathleen Groffen, John |
| Author_xml | – sequence: 1 givenname: Jan Willem surname: Voncken fullname: Voncken, Jan Willem organization: Department of Pathology Childrens Hospital of Los Angeles Los Angeles, California 90027 USA – sequence: 2 givenname: Hermien van surname: Schaick fullname: Schaick, Hermien van organization: Department of Pathology Childrens Hospital of Los Angeles Los Angeles, California 90027 USA – sequence: 3 givenname: Vesa surname: Kaartinen fullname: Kaartinen, Vesa organization: Department of Pathology Childrens Hospital of Los Angeles Los Angeles, California 90027 USA – sequence: 4 givenname: Kathleen surname: Deemer fullname: Deemer, Kathleen – sequence: 5 givenname: Thomas surname: Coates fullname: Coates, Thomas organization: Department of Hematology Childrens Hospital of Los Angeles Los Angeles, California 90027 USA – sequence: 6 givenname: Benjamin surname: Landing fullname: Landing, Benjamin organization: Department of Pathology Childrens Hospital of Los Angeles Los Angeles, California 90027 USA – sequence: 7 givenname: Paul surname: Pattengale fullname: Pattengale, Paul organization: Department of Pathology Childrens Hospital of Los Angeles Los Angeles, California 90027 USA – sequence: 8 givenname: Olivier surname: Dorseuil fullname: Dorseuil, Olivier organization: Departments of Immunology and Cell Biology Scripps Research Institute La Jolla, California 92037 USA – sequence: 9 givenname: Gary M surname: Bokoch fullname: Bokoch, Gary M organization: Departments of Immunology and Cell Biology Scripps Research Institute La Jolla, California 92037 USA – sequence: 10 givenname: John surname: Groffen fullname: Groffen, John organization: Department of Pathology Childrens Hospital of Los Angeles Los Angeles, California 90027 USA – sequence: 11 givenname: Nora surname: Heisterkamp fullname: Heisterkamp, Nora organization: Department of Pathology Childrens Hospital of Los Angeles Los Angeles, California 90027 USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/7889565$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1002/j.1460-2075.1993.tb06210.x 10.1182/blood.V81.1.158.158 10.1016/0092-8674(91)90012-N 10.1172/JCI116786 10.1182/blood.V82.4.1257.1257 10.1126/science.8438158 10.1038/351400a0 10.1128/MCB.11.4.1785 10.1016/0092-8674(91)90011-M 10.1038/354311a0 10.1038/353668a0 10.1126/science.1660188 10.1182/blood.V83.12.3441.3441 10.1016/S0021-9258(19)36716-X 10.1016/0076-6879(90)86151-K 10.1002/jlb.43.1.18 10.1016/S0021-9258(18)31748-4 10.1182/blood.V81.11.2898.2898 10.1083/jcb.121.2.449 10.1083/jcb.123.6.1597 10.1016/0092-8674(84)90077-1 10.1038/316273a0 10.1038/306239a0 10.1016/0008-8749(91)90019-8 10.1126/science.1439791 10.1002/jcp.1041000102 10.1016/S0021-9258(19)85281-X 10.1038/359414a0 10.1016/0092-8674(91)90521-Y 10.1016/0092-8674(92)90164-8 10.1016/0092-8674(92)90163-7 10.1128/MCB.11.3.1553 10.1016/S0021-9258(17)37436-7 10.1091/mbc.4.11.1217 10.1097/00000658-199310000-00005 10.1111/j.1365-2249.1993.tb03383.x 10.1002/hep.1840110205 10.1016/S0021-9258(17)32489-4 10.1016/S0021-9258(19)36882-6 10.1002/cyto.990130113 10.1016/S0021-9258(18)99959-X |
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| References | Shiratori, Tanaka, Hai, Kawase, Shirna, Sugimoto (BIB45) 1990; 11 Melo, Gordon, Cross, Goldman (BIB35) 1993; 81 Heisterkamp, Stephenson, Groffen, Hansen, de Klein, Bartram, Grosveld (BIB19) 1983; 306 Groffen, Stephenson, Heisterkamp, de Klein, Bartram, Grosveld (BIB14) 1985; 36 Hart, Maru, Leonard, Witte, Evans, Cerione (BIB18) 1992; 258 Lofgren, Ng-Sikorski, Sjolander, Andersson (BIB31) 1993; 123 Quinn, Evans, Loetterle, Jesaitis, Bokoch (BIB38) 1993; 268 Hart, Eva, Evans, Aaronson, Cerione (BIB17) 1991; 354 Ridley, Self, Kasmi, Paterson, Hall, Marshall, Ellis (BIB41) 1993; 12 Tybulewicz, Crawford, Jackson, Bronson, Mulligan (BIB47) 1991; 65 Abo, Pick, Hall, Totty, Teahan, Segal (BIB1) 1991; 353 Hewett, Schultze, VanCise, Roth (BIB23) 1992; 66 Bedi, Zehnbauer, Collector, Barber, Zicha, Sharkis, Jones (BIB3) 1993; 81 Levinovitz, Mühlhoff, Isenmann, Vestweber (BIB27) 1993; 121 Van Etten (BIB48) 1993 Ahmed, Lee, Wen, Zhao, Ho, Best, Kozma, Lim (BIB2) 1994; 269 Harlow, Lane (BIB16) 1988 McWhirter, Wang (BIB33) 1991; 11 Ridley, Hall (BIB40) 1992; 70 Shaafi, Molski, Gomez-Cambronero, Huang (BIB43) 1988; 43 Heisterkamp, Voncken, van Schaick, Groffen (BIB20) 1993 Benna, Ruedi, Babior (BIB4) 1994; 269 DeForge, Takeuchi, Nguyen, Remick (BIB7) 1994; 144 Yoshikawa, Takano, Takahashi, Ichikawa, Kondo (BIB52) 1994; 42 Liu, Campbell, Guo, Lu, Xian, Andersson, Arlinghaus (BIB28) 1993; 8 Himmelfarb, Hakim, Holbrook, Leeber, Ault (BIB24) 1992; 13 Fioretos, Heisterkamp, Groffen (BIB13) 1994; 83 Ridley, Paterson, Johnston, Diekmann, Hall (BIB39) 1992; 70 Shasby, Vanbenthuysen, Tate, Shasby, McMurtry, Repine (BIB44) 1982; 125 Haas, Argyriou-Tirita, Lion (BIB15) 1992; 359 Demling (BIB8) 1990; 30 Maru, Witte (BIB34) 1991; 67 Leung, How, Manser, Lim (BIB30) 1994; 269 Bokoch, Bohl, Chuang (BIB6) 1994; 296 Jutila, Kishimoto, Finken (BIB25) 1991; 132 Muller, Young, Pendergast, Pondel, Landau, Littman, Witte (BIB36) 1991; 11 Bokoch, Knaus (BIB5) 1994; 6 Watt, Burgess, Metcalf (BIB50) 1979; 100 Dorseuil, Vazquez, Lang, Bertoglio, Gacon, Leca (BIB10) 1992; 267 Edwards (BIB11) 1994 Wakiyama, Tsuru, Hata, Shinomiya, Shinomiya, Noritake (BIB49) 1993; 92 Heisterkamp, Kaartinen, van Soest, Bokoch, Groffen (BIB21) 1993; 268 Schwartzberg, Stall, Hardin, Bowdish, Humaran, Boast, Harbison, Robertson, Goff (BIB42) 1991; 65 Heyworth, Knaus, Settleman, Curnutte, Bokoch (BIB22) 1993; 4 Mayo, Curnutte (BIB32) 1990; 186 Wetzler, Talpaz, Van Etten, Hirsh-Ginsberg, Beran, Kurzrock (BIB51) 1993; 92 Knaus, Heyworth, Evans, Curnutte, Bokoch (BIB26) 1991; 254 Diekmann, Brill, Garrett, Totty, Hsuan, Monfries, Hall, Lim, Hall (BIB9) 1991; 351 Eva, Aaronson (BIB12) 1985; 316 Philips, Pillinger, Staud, Volker, Rosenfeld, Weissmann, Stock (BIB37) 1993; 259 Lu, Liu, Campbell, Guo, Heisterkamp, Groffen, Canaani, Arlinghaus (BIB29) 1993; 82 Simpson, Alon, Kobzik, Valeri, Shepro, Hechtman (BIB46) 1993; 218 Diekmann (10.1016/0092-8674(95)90350-X_BIB9) 1991; 351 Shaafi (10.1016/0092-8674(95)90350-X_BIB43) 1988; 43 Heisterkamp (10.1016/0092-8674(95)90350-X_BIB21) 1993; 268 Haas (10.1016/0092-8674(95)90350-X_BIB15) 1992; 359 Muller (10.1016/0092-8674(95)90350-X_BIB36) 1991; 11 Dorseuil (10.1016/0092-8674(95)90350-X_BIB10) 1992; 267 Liu (10.1016/0092-8674(95)90350-X_BIB28) 1993; 8 Schwartzberg (10.1016/0092-8674(95)90350-X_BIB42) 1991; 65 Shasby (10.1016/0092-8674(95)90350-X_BIB44) 1982; 125 Levinovitz (10.1016/0092-8674(95)90350-X_BIB27) 1993; 121 Hart (10.1016/0092-8674(95)90350-X_BIB17) 1991; 354 Demling (10.1016/0092-8674(95)90350-X_BIB8) 1990; 30 Ahmed (10.1016/0092-8674(95)90350-X_BIB2) 1994; 269 Ridley (10.1016/0092-8674(95)90350-X_BIB39) 1992; 70 Lu (10.1016/0092-8674(95)90350-X_BIB29) 1993; 82 Philips (10.1016/0092-8674(95)90350-X_BIB37) 1993; 259 Tybulewicz (10.1016/0092-8674(95)90350-X_BIB47) 1991; 65 Himmelfarb (10.1016/0092-8674(95)90350-X_BIB24) 1992; 13 Ridley (10.1016/0092-8674(95)90350-X_BIB40) 1992; 70 Ridley (10.1016/0092-8674(95)90350-X_BIB41) 1993; 12 Heisterkamp (10.1016/0092-8674(95)90350-X_BIB19) 1983; 306 Fioretos (10.1016/0092-8674(95)90350-X_BIB13) 1994; 83 Wetzler (10.1016/0092-8674(95)90350-X_BIB51) 1993; 92 Leung (10.1016/0092-8674(95)90350-X_BIB30) 1994; 269 Simpson (10.1016/0092-8674(95)90350-X_BIB46) 1993; 218 Wakiyama (10.1016/0092-8674(95)90350-X_BIB49) 1993; 92 Edwards (10.1016/0092-8674(95)90350-X_BIB11) 1994 Lofgren (10.1016/0092-8674(95)90350-X_BIB31) 1993; 123 Groffen (10.1016/0092-8674(95)90350-X_BIB14) 1985; 36 Melo (10.1016/0092-8674(95)90350-X_BIB35) 1993; 81 McWhirter (10.1016/0092-8674(95)90350-X_BIB33) 1991; 11 Bokoch (10.1016/0092-8674(95)90350-X_BIB6) 1994; 296 Yoshikawa (10.1016/0092-8674(95)90350-X_BIB52) 1994; 42 Bokoch (10.1016/0092-8674(95)90350-X_BIB5) 1994; 6 Abo (10.1016/0092-8674(95)90350-X_BIB1) 1991; 353 Harlow (10.1016/0092-8674(95)90350-X_BIB16) 1988 Eva (10.1016/0092-8674(95)90350-X_BIB12) 1985; 316 Watt (10.1016/0092-8674(95)90350-X_BIB50) 1979; 100 DeForge (10.1016/0092-8674(95)90350-X_BIB7) 1994; 144 Hewett (10.1016/0092-8674(95)90350-X_BIB23) 1992; 66 Jutila (10.1016/0092-8674(95)90350-X_BIB25) 1991; 132 Knaus (10.1016/0092-8674(95)90350-X_BIB26) 1991; 254 Bedi (10.1016/0092-8674(95)90350-X_BIB3) 1993; 81 Van Etten (10.1016/0092-8674(95)90350-X_BIB48) 1993 Heisterkamp (10.1016/0092-8674(95)90350-X_BIB20) 1993 Benna (10.1016/0092-8674(95)90350-X_BIB4) 1994; 269 Quinn (10.1016/0092-8674(95)90350-X_BIB38) 1993; 268 Shiratori (10.1016/0092-8674(95)90350-X_BIB45) 1990; 11 Maru (10.1016/0092-8674(95)90350-X_BIB34) 1991; 67 Mayo (10.1016/0092-8674(95)90350-X_BIB32) 1990; 186 Hart (10.1016/0092-8674(95)90350-X_BIB18) 1992; 258 Heyworth (10.1016/0092-8674(95)90350-X_BIB22) 1993; 4 |
| References_xml | – volume: 306 start-page: 239 year: 1983 end-page: 242 ident: BIB19 article-title: Localization of the c- publication-title: Nature contributor: fullname: Grosveld – volume: 11 start-page: 83 year: 1990 end-page: 192 ident: BIB45 article-title: Role of endotoxin-responsive macrophages in hepatic injury publication-title: Hepatology contributor: fullname: Sugimoto – volume: 92 start-page: 218 year: 1993 end-page: 224 ident: BIB49 article-title: Therapeutic effect of granulocyte colony stimulating factor and cephem antibiotics against experimental infections in neutropenic mice induced by cyclophosphamide publication-title: Clin. Exp. Immunol. contributor: fullname: Noritake – volume: 269 start-page: 6729 year: 1994 end-page: 6734 ident: BIB4 article-title: Cytosolic guanine nucleotide-binding protein Rac2 operates in vivo as a component of the neutrophil respiratory burst oxidase publication-title: J. Biol. Chem. contributor: fullname: Babior – volume: 121 start-page: 449 year: 1993 end-page: 459 ident: BIB27 article-title: Identification of a glycoprotein ligand for E-selectin on mouse myeloid cells publication-title: J. Cell. Biol. contributor: fullname: Vestweber – volume: 8 start-page: 101 year: 1993 end-page: 109 ident: BIB28 article-title: BCR-ABL tyrosine kinase is autophosphorylated or trans-phosphorylates P160 BCR on tyrosine predominantly within the first BCR exon publication-title: Oncogene contributor: fullname: Arlinghaus – volume: 12 start-page: 5151 year: 1993 end-page: 5160 ident: BIB41 article-title: rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo publication-title: EMBO J. contributor: fullname: Ellis – volume: 218 start-page: 444 year: 1993 end-page: 454 ident: BIB46 article-title: Neutrophil and nonneutrophil-mediated injury in intestinal ischemia-reperfusion publication-title: Ann. Surg. contributor: fullname: Hechtman – volume: 92 start-page: 1925 year: 1993 end-page: 1929 ident: BIB51 article-title: Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation publication-title: J. Clin. Invest. contributor: fullname: Kurzrock – volume: 81 start-page: 158 year: 1993 end-page: 165 ident: BIB35 article-title: The ABL-BCR fusion gene is expressed in chronic myelogenous leukemia publication-title: Blood contributor: fullname: Goldman – start-page: 473 year: 1988 end-page: 510 ident: BIB16 publication-title: Antibodies: A Laboratory Manual contributor: fullname: Lane – volume: 13 start-page: 83 year: 1992 end-page: 89 ident: BIB24 article-title: Detection of granulocyte reactive oxygen species formation in whole blood using flow cytometry publication-title: Cytometry contributor: fullname: Ault – volume: 144 start-page: 599 year: 1994 end-page: 611 ident: BIB7 article-title: Immunological priming attenuates the in vivo pathophysiological response to lipopolysaccharide. Comparison of cytokine production, tissue injury, and lethality in complete Freund's adjuvant-primed mice and in unprimed mice publication-title: Am. J. Pathol. contributor: fullname: Remick – volume: 296 start-page: 31674 year: 1994 end-page: 31679 ident: BIB6 article-title: Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins publication-title: J. Biol. Chem. contributor: fullname: Chuang – volume: 36 start-page: 93 year: 1985 end-page: 99 ident: BIB14 article-title: Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22 publication-title: Cell contributor: fullname: Grosveld – volume: 254 start-page: 1512 year: 1991 end-page: 1515 ident: BIB26 article-title: Regulation of the phagocyte oxygen radical production by the GTP-binding protein Rac2 publication-title: Science contributor: fullname: Bokoch – volume: 268 start-page: 20983 year: 1993 end-page: 20987 ident: BIB38 article-title: Translocation of Rae correlates with NADPH-oxidase activation publication-title: J. Biol. Chem. contributor: fullname: Bokoch – volume: 316 start-page: 273 year: 1985 end-page: 275 ident: BIB12 article-title: Isolation of a new human oncogene from a diffuse B-cell lymphoma publication-title: Nature contributor: fullname: Aaronson – volume: 258 start-page: 812 year: 1992 end-page: 815 ident: BIB18 article-title: A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42 publication-title: Science contributor: fullname: Cerione – volume: 132 start-page: 201 year: 1991 end-page: 214 ident: BIB25 article-title: Low-dose chymotrypsin treatment inhibits neutrophil migration into sites of inflammation in vivo: effects on Mac-1 and MEL-14 adhesion protein expression and function publication-title: Cell. Immunol. contributor: fullname: Finken – volume: 267 start-page: 20540 year: 1992 end-page: 20542 ident: BIB10 article-title: Inhibition of superoxide production in B lymphocytes by Rac antisense oligonucleotides publication-title: J. Biol. Chem. contributor: fullname: Leca – volume: 353 start-page: 668 year: 1991 end-page: 670 ident: BIB1 article-title: Activation of the NADPH oxidase involves the small GTPbinding protein p21 publication-title: Nature contributor: fullname: Segal – volume: 269 start-page: 12888 year: 1994 end-page: 12892 ident: BIB30 article-title: Cerebellar β2-chimaerin, a GTPase-activating protein for p21 Ras regulated Rae is specifically expressed in granule cells and has a unique N-terminal SH2 domain publication-title: J. Biol. Chem. contributor: fullname: Lim – volume: 67 start-page: 459 year: 1991 end-page: 468 ident: BIB34 article-title: The BCR gene encodes a novel serinelthreonine kinase activity within a single exon publication-title: Cell contributor: fullname: Witte – volume: 65 start-page: 1153 year: 1991 end-page: 1163 ident: BIB47 article-title: Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c- publication-title: Cell contributor: fullname: Mulligan – volume: 6 start-page: 98 year: 1994 end-page: 105 ident: BIB5 article-title: The role of small GTP-binding proteins in leukocyte function publication-title: Curr. Opin. Cell Biol. contributor: fullname: Knaus – volume: 65 start-page: 1165 year: 1991 end-page: 1175 ident: BIB42 article-title: Mice homologous for the publication-title: Cell contributor: fullname: Goff – volume: 4 start-page: 1217 year: 1993 end-page: 1223 ident: BIB22 article-title: Regulation of NADPH oxidase activity by Rac GTPase activating protein(s) publication-title: Mol. Biol. Cell. contributor: fullname: Bokoch – volume: 11 start-page: 1553 year: 1991 end-page: 1565 ident: BIB33 article-title: Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins publication-title: Mol. Cell. Biol. contributor: fullname: Wang – volume: 43 start-page: 18 year: 1988 end-page: 27 ident: BIB43 article-title: Dissociation of the 47-kilodalton protein phosphorylation from degranulation and superoxide production in neutrophils publication-title: J. Leuk. Biol. contributor: fullname: Huang – start-page: 235 year: 1994 end-page: 262 ident: BIB11 article-title: Biochemistry and Physiology of the Neutrophil contributor: fullname: Edwards – volume: 268 start-page: 16903 year: 1993 end-page: 16906 ident: BIB21 article-title: Human publication-title: J. Biol. Chem. contributor: fullname: Groffen – volume: 123 start-page: 1597 year: 1993 end-page: 1605 ident: BIB31 article-title: Beta 2 integrin engagement triggers actin polymerization and phosphatidylinositol triphosphate formation in non-adherent human neutrophils publication-title: J. Cell Biol. contributor: fullname: Andersson – volume: 81 start-page: 2898 year: 1993 end-page: 2902 ident: BIB3 article-title: BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia publication-title: Blood contributor: fullname: Jones – volume: 125 start-page: 443 year: 1982 end-page: 447 ident: BIB44 article-title: Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals publication-title: Am. Rev. Resp. Dis. contributor: fullname: Repine – volume: 30 start-page: 297 year: 1990 end-page: 309 ident: BIB8 article-title: Current concepts on the adult respiratory distress syndrome publication-title: Circ. Shock contributor: fullname: Demling – volume: 83 start-page: 3441 year: 1994 end-page: 3444 ident: BIB13 article-title: No evidence for genomic imprinting of the human publication-title: Blood contributor: fullname: Groffen – volume: 351 start-page: 400 year: 1991 end-page: 403 ident: BIB9 article-title: publication-title: Nature contributor: fullname: Hall – volume: 70 start-page: 389 year: 1992 end-page: 399 ident: BIB40 article-title: The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors publication-title: Cell contributor: fullname: Hall – volume: 259 start-page: 977 year: 1993 end-page: 980 ident: BIB37 article-title: Carboxyl methylation of Rasrelated proteins during signal transduction in neutrophils publication-title: Science contributor: fullname: Stock – volume: 186 start-page: 567 year: 1990 end-page: 575 ident: BIB32 article-title: Kinetic microplate assay for superoxide production by neutrophils and other phagocytic cells publication-title: Meth. Enzymol. contributor: fullname: Curnutte – volume: 82 start-page: 1257 year: 1993 end-page: 1263 ident: BIB29 article-title: Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL publication-title: Blood contributor: fullname: Arlinghaus – volume: 42 start-page: 53 year: 1994 end-page: 58 ident: BIB52 article-title: Changes in tissue antioxidant enzyme activities and lipid peroxides in endotoxin-induced multiple organ failure publication-title: Circ. Shock contributor: fullname: Kondo – volume: 269 start-page: 17642 year: 1994 end-page: 17646 ident: BIB2 article-title: Breakpoint cluster region gene product-related domain of n-chimaerin publication-title: J. Biol. Chem. contributor: fullname: Lim – volume: 66 start-page: 347 year: 1992 end-page: 361 ident: BIB23 article-title: Neutrophil depletion protects against liver injury from bacterial endotoxin publication-title: Lab. Invest. contributor: fullname: Roth – volume: 11 start-page: 1785 year: 1991 end-page: 1792 ident: BIB36 article-title: BCR first axon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias publication-title: Mol. Cell. Biol. contributor: fullname: Witte – start-page: 295 year: 1993 end-page: 325 ident: BIB48 article-title: The molecular pathogenesis of the Philadelphia-positive leukemias: implications for diagnosis and therapy publication-title: Leukemia: Advances in Research and Treatment contributor: fullname: Van Etten – volume: 354 start-page: 311 year: 1991 end-page: 314 ident: BIB17 article-title: Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product publication-title: Nature contributor: fullname: Cerione – start-page: 359 year: 1993 end-page: 376 ident: BIB20 article-title: Ph-positive leukemia publication-title: The Causes and Consequences of Chromosomal Aberrations contributor: fullname: Groffen – volume: 100 start-page: 1 year: 1979 end-page: 22 ident: BIB50 article-title: Isolation and surface labeling of murine polymorphonuclear neutrophils publication-title: J. Cell. Physiol. contributor: fullname: Metcalf – volume: 70 start-page: 401 year: 1992 end-page: 410 ident: BIB39 article-title: The small GTP-binding protein roc regulates growth factorinduced membrane ruffling publication-title: Cell contributor: fullname: Hall – volume: 359 start-page: 414 year: 1992 end-page: 416 ident: BIB15 article-title: Parental origin of chromosomes involved in the translocation t(9;22) publication-title: Nature contributor: fullname: Lion – volume: 12 start-page: 5151 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB41 article-title: rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo publication-title: EMBO J. doi: 10.1002/j.1460-2075.1993.tb06210.x contributor: fullname: Ridley – volume: 81 start-page: 158 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB35 article-title: The ABL-BCR fusion gene is expressed in chronic myelogenous leukemia publication-title: Blood doi: 10.1182/blood.V81.1.158.158 contributor: fullname: Melo – volume: 66 start-page: 347 year: 1992 ident: 10.1016/0092-8674(95)90350-X_BIB23 article-title: Neutrophil depletion protects against liver injury from bacterial endotoxin publication-title: Lab. Invest. contributor: fullname: Hewett – volume: 65 start-page: 1165 year: 1991 ident: 10.1016/0092-8674(95)90350-X_BIB42 article-title: Mice homologous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations publication-title: Cell doi: 10.1016/0092-8674(91)90012-N contributor: fullname: Schwartzberg – volume: 92 start-page: 1925 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB51 article-title: Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation publication-title: J. Clin. Invest. doi: 10.1172/JCI116786 contributor: fullname: Wetzler – volume: 82 start-page: 1257 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB29 article-title: Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL publication-title: Blood doi: 10.1182/blood.V82.4.1257.1257 contributor: fullname: Lu – volume: 259 start-page: 977 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB37 article-title: Carboxyl methylation of Rasrelated proteins during signal transduction in neutrophils publication-title: Science doi: 10.1126/science.8438158 contributor: fullname: Philips – volume: 351 start-page: 400 year: 1991 ident: 10.1016/0092-8674(95)90350-X_BIB9 article-title: Bcr encodes a GTPase-activating protein for p21rac publication-title: Nature doi: 10.1038/351400a0 contributor: fullname: Diekmann – volume: 11 start-page: 1785 year: 1991 ident: 10.1016/0092-8674(95)90350-X_BIB36 article-title: BCR first axon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.11.4.1785 contributor: fullname: Muller – volume: 65 start-page: 1153 year: 1991 ident: 10.1016/0092-8674(95)90350-X_BIB47 article-title: Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene publication-title: Cell doi: 10.1016/0092-8674(91)90011-M contributor: fullname: Tybulewicz – volume: 354 start-page: 311 year: 1991 ident: 10.1016/0092-8674(95)90350-X_BIB17 article-title: Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product publication-title: Nature doi: 10.1038/354311a0 contributor: fullname: Hart – volume: 353 start-page: 668 year: 1991 ident: 10.1016/0092-8674(95)90350-X_BIB1 article-title: Activation of the NADPH oxidase involves the small GTPbinding protein p21rac1 publication-title: Nature doi: 10.1038/353668a0 contributor: fullname: Abo – volume: 6 start-page: 98 year: 1994 ident: 10.1016/0092-8674(95)90350-X_BIB5 article-title: The role of small GTP-binding proteins in leukocyte function publication-title: Curr. Opin. Cell Biol. contributor: fullname: Bokoch – volume: 254 start-page: 1512 year: 1991 ident: 10.1016/0092-8674(95)90350-X_BIB26 article-title: Regulation of the phagocyte oxygen radical production by the GTP-binding protein Rac2 publication-title: Science doi: 10.1126/science.1660188 contributor: fullname: Knaus – start-page: 359 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB20 article-title: Ph-positive leukemia contributor: fullname: Heisterkamp – volume: 83 start-page: 3441 year: 1994 ident: 10.1016/0092-8674(95)90350-X_BIB13 article-title: No evidence for genomic imprinting of the human BCR gene publication-title: Blood doi: 10.1182/blood.V83.12.3441.3441 contributor: fullname: Fioretos – volume: 267 start-page: 20540 year: 1992 ident: 10.1016/0092-8674(95)90350-X_BIB10 article-title: Inhibition of superoxide production in B lymphocytes by Rac antisense oligonucleotides publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)36716-X contributor: fullname: Dorseuil – volume: 186 start-page: 567 year: 1990 ident: 10.1016/0092-8674(95)90350-X_BIB32 article-title: Kinetic microplate assay for superoxide production by neutrophils and other phagocytic cells publication-title: Meth. Enzymol. doi: 10.1016/0076-6879(90)86151-K contributor: fullname: Mayo – volume: 43 start-page: 18 year: 1988 ident: 10.1016/0092-8674(95)90350-X_BIB43 article-title: Dissociation of the 47-kilodalton protein phosphorylation from degranulation and superoxide production in neutrophils publication-title: J. Leuk. Biol. doi: 10.1002/jlb.43.1.18 contributor: fullname: Shaafi – volume: 296 start-page: 31674 year: 1994 ident: 10.1016/0092-8674(95)90350-X_BIB6 article-title: Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)31748-4 contributor: fullname: Bokoch – volume: 81 start-page: 2898 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB3 article-title: BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia publication-title: Blood doi: 10.1182/blood.V81.11.2898.2898 contributor: fullname: Bedi – volume: 121 start-page: 449 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB27 article-title: Identification of a glycoprotein ligand for E-selectin on mouse myeloid cells publication-title: J. Cell. Biol. doi: 10.1083/jcb.121.2.449 contributor: fullname: Levinovitz – volume: 123 start-page: 1597 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB31 article-title: Beta 2 integrin engagement triggers actin polymerization and phosphatidylinositol triphosphate formation in non-adherent human neutrophils publication-title: J. Cell Biol. doi: 10.1083/jcb.123.6.1597 contributor: fullname: Lofgren – volume: 36 start-page: 93 year: 1985 ident: 10.1016/0092-8674(95)90350-X_BIB14 article-title: Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22 publication-title: Cell doi: 10.1016/0092-8674(84)90077-1 contributor: fullname: Groffen – volume: 316 start-page: 273 year: 1985 ident: 10.1016/0092-8674(95)90350-X_BIB12 article-title: Isolation of a new human oncogene from a diffuse B-cell lymphoma publication-title: Nature doi: 10.1038/316273a0 contributor: fullname: Eva – volume: 306 start-page: 239 year: 1983 ident: 10.1016/0092-8674(95)90350-X_BIB19 article-title: Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukemia publication-title: Nature doi: 10.1038/306239a0 contributor: fullname: Heisterkamp – volume: 132 start-page: 201 year: 1991 ident: 10.1016/0092-8674(95)90350-X_BIB25 article-title: Low-dose chymotrypsin treatment inhibits neutrophil migration into sites of inflammation in vivo: effects on Mac-1 and MEL-14 adhesion protein expression and function publication-title: Cell. Immunol. doi: 10.1016/0008-8749(91)90019-8 contributor: fullname: Jutila – volume: 258 start-page: 812 year: 1992 ident: 10.1016/0092-8674(95)90350-X_BIB18 article-title: A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42 publication-title: Science doi: 10.1126/science.1439791 contributor: fullname: Hart – volume: 100 start-page: 1 year: 1979 ident: 10.1016/0092-8674(95)90350-X_BIB50 article-title: Isolation and surface labeling of murine polymorphonuclear neutrophils publication-title: J. Cell. Physiol. doi: 10.1002/jcp.1041000102 contributor: fullname: Watt – volume: 8 start-page: 101 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB28 article-title: BCR-ABL tyrosine kinase is autophosphorylated or trans-phosphorylates P160 BCR on tyrosine predominantly within the first BCR exon publication-title: Oncogene contributor: fullname: Liu – start-page: 235 year: 1994 ident: 10.1016/0092-8674(95)90350-X_BIB11 article-title: Biochemistry and Physiology of the Neutrophil contributor: fullname: Edwards – volume: 268 start-page: 16903 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB21 article-title: Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)85281-X contributor: fullname: Heisterkamp – volume: 359 start-page: 414 year: 1992 ident: 10.1016/0092-8674(95)90350-X_BIB15 article-title: Parental origin of chromosomes involved in the translocation t(9;22) publication-title: Nature doi: 10.1038/359414a0 contributor: fullname: Haas – volume: 67 start-page: 459 year: 1991 ident: 10.1016/0092-8674(95)90350-X_BIB34 article-title: The BCR gene encodes a novel serinelthreonine kinase activity within a single exon publication-title: Cell doi: 10.1016/0092-8674(91)90521-Y contributor: fullname: Maru – volume: 30 start-page: 297 year: 1990 ident: 10.1016/0092-8674(95)90350-X_BIB8 article-title: Current concepts on the adult respiratory distress syndrome publication-title: Circ. Shock contributor: fullname: Demling – volume: 144 start-page: 599 year: 1994 ident: 10.1016/0092-8674(95)90350-X_BIB7 article-title: Immunological priming attenuates the in vivo pathophysiological response to lipopolysaccharide. Comparison of cytokine production, tissue injury, and lethality in complete Freund's adjuvant-primed mice and in unprimed mice publication-title: Am. J. Pathol. contributor: fullname: DeForge – volume: 70 start-page: 401 year: 1992 ident: 10.1016/0092-8674(95)90350-X_BIB39 article-title: The small GTP-binding protein roc regulates growth factorinduced membrane ruffling publication-title: Cell doi: 10.1016/0092-8674(92)90164-8 contributor: fullname: Ridley – volume: 70 start-page: 389 year: 1992 ident: 10.1016/0092-8674(95)90350-X_BIB40 article-title: The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors publication-title: Cell doi: 10.1016/0092-8674(92)90163-7 contributor: fullname: Ridley – volume: 11 start-page: 1553 year: 1991 ident: 10.1016/0092-8674(95)90350-X_BIB33 article-title: Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.11.3.1553 contributor: fullname: McWhirter – volume: 269 start-page: 6729 year: 1994 ident: 10.1016/0092-8674(95)90350-X_BIB4 article-title: Cytosolic guanine nucleotide-binding protein Rac2 operates in vivo as a component of the neutrophil respiratory burst oxidase publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)37436-7 contributor: fullname: Benna – volume: 4 start-page: 1217 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB22 article-title: Regulation of NADPH oxidase activity by Rac GTPase activating protein(s) publication-title: Mol. Biol. Cell. doi: 10.1091/mbc.4.11.1217 contributor: fullname: Heyworth – volume: 218 start-page: 444 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB46 article-title: Neutrophil and nonneutrophil-mediated injury in intestinal ischemia-reperfusion publication-title: Ann. Surg. doi: 10.1097/00000658-199310000-00005 contributor: fullname: Simpson – volume: 92 start-page: 218 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB49 article-title: Therapeutic effect of granulocyte colony stimulating factor and cephem antibiotics against experimental infections in neutropenic mice induced by cyclophosphamide publication-title: Clin. Exp. Immunol. doi: 10.1111/j.1365-2249.1993.tb03383.x contributor: fullname: Wakiyama – volume: 125 start-page: 443 year: 1982 ident: 10.1016/0092-8674(95)90350-X_BIB44 article-title: Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals publication-title: Am. Rev. Resp. Dis. contributor: fullname: Shasby – volume: 11 start-page: 83 year: 1990 ident: 10.1016/0092-8674(95)90350-X_BIB45 article-title: Role of endotoxin-responsive macrophages in hepatic injury publication-title: Hepatology doi: 10.1002/hep.1840110205 contributor: fullname: Shiratori – start-page: 295 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB48 article-title: The molecular pathogenesis of the Philadelphia-positive leukemias: implications for diagnosis and therapy contributor: fullname: Van Etten – start-page: 473 year: 1988 ident: 10.1016/0092-8674(95)90350-X_BIB16 contributor: fullname: Harlow – volume: 42 start-page: 53 year: 1994 ident: 10.1016/0092-8674(95)90350-X_BIB52 article-title: Changes in tissue antioxidant enzyme activities and lipid peroxides in endotoxin-induced multiple organ failure publication-title: Circ. Shock contributor: fullname: Yoshikawa – volume: 269 start-page: 17642 year: 1994 ident: 10.1016/0092-8674(95)90350-X_BIB2 article-title: Breakpoint cluster region gene product-related domain of n-chimaerin publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)32489-4 contributor: fullname: Ahmed – volume: 268 start-page: 20983 year: 1993 ident: 10.1016/0092-8674(95)90350-X_BIB38 article-title: Translocation of Rae correlates with NADPH-oxidase activation publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)36882-6 contributor: fullname: Quinn – volume: 13 start-page: 83 year: 1992 ident: 10.1016/0092-8674(95)90350-X_BIB24 article-title: Detection of granulocyte reactive oxygen species formation in whole blood using flow cytometry publication-title: Cytometry doi: 10.1002/cyto.990130113 contributor: fullname: Himmelfarb – volume: 269 start-page: 12888 year: 1994 ident: 10.1016/0092-8674(95)90350-X_BIB30 article-title: Cerebellar β2-chimaerin, a GTPase-activating protein for p21 Ras regulated Rae is specifically expressed in granule cells and has a unique N-terminal SH2 domain publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)99959-X contributor: fullname: Leung |
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| Snippet | Philadelphia (Ph)-positive leukemias invariably contain a chromosomal translocation fusing
BCR to
ABL. The BCR-ABL protein is responsible for leukemogenesis.... Philadelphia (Ph)-positive leukemias invariably contain a chromosomal translocation fusing BCR to ABL. The BCR-ABL protein is responsible for leukemogenesis.... |
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| SubjectTerms | Actin Cytoskeleton - physiology Animals Endotoxins - toxicity Female Gene Targeting GTP-Binding Proteins - biosynthesis GTP-Binding Proteins - metabolism Lipopolysaccharides - pharmacology Male Mice Mice, Inbred C57BL Mutation - physiology Neutropenia - chemically induced Neutropenia - immunology Neutrophil Activation Neutrophils - metabolism Oncogene Proteins - genetics Oncogene Proteins - physiology Protein-Tyrosine Kinases Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcr rac GTP-Binding Proteins Respiratory Burst - immunology Shock, Septic - chemically induced Shock, Septic - immunology Shock, Septic - pathology Superoxides - metabolism Toxemia - chemically induced Toxemia - immunology Toxemia - pathology |
| Title | Increased neutrophil respiratory burst in bcr-null mutants |
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