Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues

• Published in: BMC genomics Vol. 26; no. 1; pp. 289 - 15
• Main Authors: Peng, Shisheng, Fang, Jinlong, Mo, Weiliang, Hu, Guodong, Wu, Senquan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.03.2025; BioMed Central; BMC
• Subjects: Bayesian analysis; Biological analysis; Blood; Blood cells; CD46 antigen; Chronic obstructive pulmonary disease; Cross-tissue targets; Datasets; Deoxyribonucleic acid; DNA; DNA Methylation; Epigenetics; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Gene loci; Gene mapping; Genes; Genetic analysis; Genetic aspects; Genetic research; Genome-wide association studies; Genome-Wide Association Study; Genomes; Human tissues; Humans; Lung - metabolism; Lung - physiology; Lung diseases; Lung function; Lungs; Methylation; Multi-omics analysis; Multiomics; Organ Specificity - genetics; Phenotypes; Physiological aspects; Protein expression; Proteins; Quantitative Trait Loci; Respiratory function; Tissues; China; DNA methylation; Lung function; Cross-tissue targets; Gene expression; Multi-omics analysis

Previous studies have reported several genetic loci associated with lung function. However, the mediating mechanism between these genetic loci and lung function phenotype is rarely explored. In this research, we used a cross-tissue multi-omics post-GWAS analysis to explain the associations between D...