Triacylglycerols sequester monotopic membrane proteins to lipid droplets

• Published in: Nature communications Vol. 11; no. 1; p. 3944
• Main Authors: Caillon, Lucie, Nieto, Vincent, Gehan, Pauline, Omrane, Mohyeddine, Rodriguez, Nicolas, Monticelli, Luca, Thiam, Abdou Rachid
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.08.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 631/57/2270; 639/766/747; Droplets; Endoplasmic reticulum; Humanities and Social Sciences; Hydrophobicity; Integral membrane proteins; Life Sciences; Lipids; Membranes; Monolayers; multidisciplinary; Organelles; Partitions; Phospholipids; Proteins; Relocation; Science; Science (multidisciplinary); Synthesis; Triglycerides

Triacylglycerols (TG) are synthesized at the endoplasmic reticulum (ER) bilayer and packaged into organelles called lipid droplets (LDs). LDs are covered by a single phospholipid monolayer contiguous with the ER bilayer. This connection is used by several monotopic integral membrane proteins, with h...