Synbiotic-driven modulation of the gut microbiota and metabolic functions related to obesity: insights from a human gastrointestinal model

• Published in: BMC microbiology Vol. 25; no. 1; pp. 250 - 15
• Main Authors: Mok, Kevin, Tomtong, Putsawee, Ogawa, Takuma, Nagai, Kenshiro, Torrungruang, Pitchsupang, Charoensiddhi, Suvimol, Nakayama, Jiro, Wanikorn, Bandhita, Nitisinprasert, Sunee, Vongsangnak, Wanwipa, Nakphaichit, Massalin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.04.2025; BioMed Central; BMC
• Subjects: Adult; Bacteria; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; Bacteria - metabolism; Bile acids; Body weight; Care and treatment; Cholesterol; Colon; Community composition; Complications and side effects; Composition; Cresols; Culture; Development and progression; Dietary supplements; Digestive system; Dosage and administration; Feces; Feces - microbiology; Female; Fermentation; Gastrointestinal Microbiome; Gastrointestinal tract; Gastrointestinal Tract - metabolism; Gastrointestinal Tract - microbiology; Gut microbiota; Humans; In vitro gastrointestinal model; Inflammation; Intestinal microflora; Laboratories; Lactic acid; Lactic acid bacteria; Limosilactobacillus reuteri - growth & development; Limosilactobacillus reuteri KUB-AC5; Lipid metabolism; Lipids; Male; Medical research; Medicine, Experimental; Metabolic diseases; Metabolism; Metabolites; Metagenomics; Microbial Viability; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Nitrogen; Obesity; Obesity - metabolism; Obesity - microbiology; Physiological aspects; Prebiotics; Probiotics; Small intestine; Statistical analysis; Synbiotic; Synbiotics - administration & dosage; Wolffia globosa; Thailand; California; United States; Massachusetts; Germany; Gut microbiota; Obesity; In vitro gastrointestinal model; Synbiotic; Wolffia globosa; Limosilactobacillus reuteri KUB-AC5

Synbiotic interventions have gained increasing attention for modulating gut microbiota and metabolic functions in obesity-related disorders. This study evaluated the effects of Limosilactobacillus reuteri KUB-AC5 (10⁸ CFU) and Wolffia globosa powder (6 g/day) using an in vitro continuous human gastr...