Cryo-electron microscopy for structural analysis of dynamic biological macromolecules

• Published in: Biochimica et biophysica acta Vol. 1862; no. 2; pp. 324 - 334
• Main Authors: Murata, Kazuyoshi, Wolf, Matthias
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2018
• Subjects: algorithms; biochemical compounds; cryo-electron microscopy; Cryo-electron tomography; Electron cryomicroscopy; Molecular dynamics; Protein structure; Single particle 3D reconstruction; Molecular dynamics; Cryo-electron tomography; Single particle 3D reconstruction; Protein structure; Electron cryomicroscopy

Since the introduction of what became today's standard for cryo-embedding of biological macromolecules at native conditions more than 30years ago, techniques and equipment have been drastically improved and the structure of biomolecules can now be studied at near atomic resolution by cryo-elect...