Computer simulations of heterologous immunity: Highlights of an interdisciplinary cooperation

• Published in: Autoimmunity (Chur, Switzerland) Vol. 44; no. 4; pp. 304 - 314
• Main Authors: Calcagno, Claudia, Puzone, Roberto, Pearson, Yanthe E., Cheng, Yiming, Ghersi, Dario, Selin, Liisa K., Welsh, Raymond M., Celada, Franco
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.06.2011; Taylor & Francis
• Subjects: Animals; attrition; Computer applications; Computer Simulation; Cross Reactions - immunology; heterologous memory; Humans; IMMSIM simulator; Immunity - immunology; Immunologic Memory - immunology; Interdisciplinary Studies; repertoire changes

The relationship between biological research and mathematical modeling is complex, critical, and vital. In this review, we summarize the results of the collaboration between two laboratories, exploring the interaction between mathematical modeling and wet-lab immunology. During this collaboration se...