Short-term hyperglycemia increases arterial superoxide production and iron dysregulation in atherosclerotic monkeys

• Published in: Metabolism, clinical and experimental Vol. 60; no. 8; pp. 1070 - 1080
• Main Authors: Rowe, Patrick A, Kavanagh, Kylie, Zhang, Li, Harwood, H. James, Wagner, Janice D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2011; Elsevier
• Subjects: Animals; Arteries - metabolism; Atherosclerosis (general aspects, experimental research); Atherosclerosis - metabolism; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Catalase - metabolism; Diabetes Mellitus, Experimental - metabolism; Diet, Atherogenic; Dietary Fats; Endocrinology & Metabolism; Feeding. Feeding behavior; Ferritins - blood; Fundamental and applied biological sciences. Psychology; Heme Oxygenase-1 - metabolism; Hyperglycemia - metabolism; Iron - metabolism; Lipids - blood; Macaca fascicularis; Medical sciences; Oxidative Stress - physiology; Superoxide Dismutase - metabolism; Superoxides - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Short term; Monkey; Cardiovascular disease; Increase; Iron; Artery; Vascular disease; Vertebrata; Hyperglycemia; Mammalia; Blood vessel; Animal; Atherosclerosis; Production; Primates; Circulatory system; Endocrinology

Abstract The incidence and severity of atherosclerotic vascular disease are increased in diabetic patients, in part because of increased production of reactive oxygen species (ROS). Previously, we found both increased atherosclerosis and arterial protein oxidation 6 months after streptozotocin-induc...