Perinatal Distress Leads to Lateralized Medial Prefrontal Cortical Dopamine Hypofunction in Adult Rats

• Published in: The Journal of neuroscience Vol. 20; no. 14; pp. 5538 - 5543
• Main Authors: Brake, Wayne G, Sullivan, Ron M, Gratton, Alain
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 15.07.2000; Society for Neuroscience
• Subjects: Analysis of Variance; Animals; Carrier Proteins - metabolism; Cesarean Section; Dopamine - metabolism; Dopamine Plasma Membrane Transport Proteins; Female; Fetal Hypoxia - physiopathology; Functional Laterality; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Nerve Tissue Proteins; Prefrontal Cortex - physiopathology; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Dopamine - metabolism

Obstetric complications involving anoxia or prolonged hypoxia are suspected to increase the risk for such mental disorders as schizophrenia and attention deficit-hyperactivity disorder. In previous studies, we reported evidence of enhanced nucleus accumbens (NAcc) dopamine (DA) function in adult rat...