Perinatal Distress Leads to Lateralized Medial Prefrontal Cortical Dopamine Hypofunction in Adult Rats
Obstetric complications involving anoxia or prolonged hypoxia are suspected to increase the risk for such mental disorders as schizophrenia and attention deficit-hyperactivity disorder. In previous studies, we reported evidence of enhanced nucleus accumbens (NAcc) dopamine (DA) function in adult rat...
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Published in | The Journal of neuroscience Vol. 20; no. 14; pp. 5538 - 5543 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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United States
Soc Neuroscience
15.07.2000
Society for Neuroscience |
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Abstract | Obstetric complications involving anoxia or prolonged hypoxia are suspected to increase the risk for such mental disorders as schizophrenia and attention deficit-hyperactivity disorder. In previous studies, we reported evidence of enhanced nucleus accumbens (NAcc) dopamine (DA) function in adult rats subjected to intrauterine anoxia during cesarean (C) section birth. In the present study, we used voltammetry and monoamine-sensitive electrodes to investigate the possibility that this functional hyperactivity of the meso-NAcc system is attributable to a loss of inhibitory control from the medial prefrontal cortex (PFC). We monitored the DA responses to repeated once-daily stress in the right or left PFC of adult male rats born vaginally (VAG) or by C-section, either with (C + 15) or without (C + 0) an additional 15 min of intrauterine anoxia. In C + 15 animals, we observed a pronounced and persistent blunting of stress-induced DA release in the right PFC but not in the left; with repeated testing, a similar pattern of dampened right PFC DA stress responses emerged in C + 0 animals. In addition, C + 15 animals were spontaneously more active than VAG and C + 0 animals and displayed an increase in PFC DA transporter density that was also lateralized to the right hemisphere. There was no evidence, however, that PFC D(1) and D(2) receptor levels differed between birth groups or hemisphere. These findings suggest a mechanism by which perinatal complications involving anoxia might contribute to the etiology of mental disorders that have been linked to disturbances in central DA transmission and lateralized PFC dysfunction. |
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AbstractList | Obstetric complications involving anoxia or prolonged hypoxia are suspected to increase the risk for such mental disorders as schizophrenia and attention deficit-hyperactivity disorder. In previous studies, we reported evidence of enhanced nucleus accumbens (NAcc) dopamine (DA) function in adult rats subjected to intrauterine anoxia during cesarean (C) section birth. In the present study, we used voltammetry and monoamine-sensitive electrodes to investigate the possibility that this functional hyperactivity of the meso-NAcc system is attributable to a loss of inhibitory control from the medial prefrontal cortex (PFC). We monitored the DA responses to repeated once-daily stress in the right or left PFC of adult male rats born vaginally (VAG) or by C-section, either with (C + 15) or without (C + 0) an additional 15 min of intrauterine anoxia. In C + 15 animals, we observed a pronounced and persistent blunting of stress-induced DA release in the right PFC but not in the left; with repeated testing, a similar pattern of dampened right PFC DA stress responses emerged in C + 0 animals. In addition, C + 15 animals were spontaneously more active than VAG and C + 0 animals and displayed an increase in PFC DA transporter density that was also lateralized to the right hemisphere. There was no evidence, however, that PFC D sub(1) and D sub(2) receptor levels differed between birth groups or hemisphere. These findings suggest a mechanism by which perinatal complications involving anoxia might contribute to the etiology of mental disorders that have been linked to disturbances in central DA transmission and lateralized PFC dysfunction. Obstetric complications involving anoxia or prolonged hypoxia are suspected to increase the risk for such mental disorders as schizophrenia and attention deficit–hyperactivity disorder. In previous studies, we reported evidence of enhanced nucleus accumbens (NAcc) dopamine (DA) function in adult rats subjected to intrauterine anoxia during cesarean (C) section birth. In the present study, we used voltammetry and monoamine-sensitive electrodes to investigate the possibility that this functional hyperactivity of the meso-NAcc system is attributable to a loss of inhibitory control from the medial prefrontal cortex (PFC). We monitored the DA responses to repeated once-daily stress in the right or left PFC of adult male rats born vaginally (VAG) or by C-section, either with (C + 15) or without (C + 0) an additional 15 min of intrauterine anoxia. In C + 15 animals, we observed a pronounced and persistent blunting of stress-induced DA release in the right PFC but not in the left; with repeated testing, a similar pattern of dampened right PFC DA stress responses emerged in C + 0 animals. In addition, C + 15 animals were spontaneously more active than VAG and C + 0 animals and displayed an increase in PFC DA transporter density that was also lateralized to the right hemisphere. There was no evidence, however, that PFC D 1 and D 2 receptor levels differed between birth groups or hemisphere. These findings suggest a mechanism by which perinatal complications involving anoxia might contribute to the etiology of mental disorders that have been linked to disturbances in central DA transmission and lateralized PFC dysfunction. Obstetric complications involving anoxia or prolonged hypoxia are suspected to increase the risk for such mental disorders as schizophrenia and attention deficit-hyperactivity disorder. In previous studies, we reported evidence of enhanced nucleus accumbens (NAcc) dopamine (DA) function in adult rats subjected to intrauterine anoxia during cesarean (C) section birth. In the present study, we used voltammetry and monoamine-sensitive electrodes to investigate the possibility that this functional hyperactivity of the meso-NAcc system is attributable to a loss of inhibitory control from the medial prefrontal cortex (PFC). We monitored the DA responses to repeated once-daily stress in the right or left PFC of adult male rats born vaginally (VAG) or by C-section, either with (C + 15) or without (C + 0) an additional 15 min of intrauterine anoxia. In C + 15 animals, we observed a pronounced and persistent blunting of stress-induced DA release in the right PFC but not in the left; with repeated testing, a similar pattern of dampened right PFC DA stress responses emerged in C + 0 animals. In addition, C + 15 animals were spontaneously more active than VAG and C + 0 animals and displayed an increase in PFC DA transporter density that was also lateralized to the right hemisphere. There was no evidence, however, that PFC D(1) and D(2) receptor levels differed between birth groups or hemisphere. These findings suggest a mechanism by which perinatal complications involving anoxia might contribute to the etiology of mental disorders that have been linked to disturbances in central DA transmission and lateralized PFC dysfunction.Obstetric complications involving anoxia or prolonged hypoxia are suspected to increase the risk for such mental disorders as schizophrenia and attention deficit-hyperactivity disorder. In previous studies, we reported evidence of enhanced nucleus accumbens (NAcc) dopamine (DA) function in adult rats subjected to intrauterine anoxia during cesarean (C) section birth. In the present study, we used voltammetry and monoamine-sensitive electrodes to investigate the possibility that this functional hyperactivity of the meso-NAcc system is attributable to a loss of inhibitory control from the medial prefrontal cortex (PFC). We monitored the DA responses to repeated once-daily stress in the right or left PFC of adult male rats born vaginally (VAG) or by C-section, either with (C + 15) or without (C + 0) an additional 15 min of intrauterine anoxia. In C + 15 animals, we observed a pronounced and persistent blunting of stress-induced DA release in the right PFC but not in the left; with repeated testing, a similar pattern of dampened right PFC DA stress responses emerged in C + 0 animals. In addition, C + 15 animals were spontaneously more active than VAG and C + 0 animals and displayed an increase in PFC DA transporter density that was also lateralized to the right hemisphere. There was no evidence, however, that PFC D(1) and D(2) receptor levels differed between birth groups or hemisphere. These findings suggest a mechanism by which perinatal complications involving anoxia might contribute to the etiology of mental disorders that have been linked to disturbances in central DA transmission and lateralized PFC dysfunction. Obstetric complications involving anoxia or prolonged hypoxia are suspected to increase the risk for such mental disorders as schizophrenia and attention deficit-hyperactivity disorder. In previous studies, we reported evidence of enhanced nucleus accumbens (NAcc) dopamine (DA) function in adult rats subjected to intrauterine anoxia during cesarean (C) section birth. In the present study, we used voltammetry and monoamine-sensitive electrodes to investigate the possibility that this functional hyperactivity of the meso-NAcc system is attributable to a loss of inhibitory control from the medial prefrontal cortex (PFC). We monitored the DA responses to repeated once-daily stress in the right or left PFC of adult male rats born vaginally (VAG) or by C-section, either with (C + 15) or without (C + 0) an additional 15 min of intrauterine anoxia. In C + 15 animals, we observed a pronounced and persistent blunting of stress-induced DA release in the right PFC but not in the left; with repeated testing, a similar pattern of dampened right PFC DA stress responses emerged in C + 0 animals. In addition, C + 15 animals were spontaneously more active than VAG and C + 0 animals and displayed an increase in PFC DA transporter density that was also lateralized to the right hemisphere. There was no evidence, however, that PFC D(1) and D(2) receptor levels differed between birth groups or hemisphere. These findings suggest a mechanism by which perinatal complications involving anoxia might contribute to the etiology of mental disorders that have been linked to disturbances in central DA transmission and lateralized PFC dysfunction. |
Author | Gratton, Alain Sullivan, Ron M Brake, Wayne G |
AuthorAffiliation | 1 Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, and 2 Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montréal, Canada H4H 1R3 |
AuthorAffiliation_xml | – name: 2 Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montréal, Canada H4H 1R3 – name: 1 Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, and |
Author_xml | – sequence: 1 fullname: Brake, Wayne G – sequence: 2 fullname: Sullivan, Ron M – sequence: 3 fullname: Gratton, Alain |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10884337$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1126/science.462179 10.1007/PL00005670 10.1038/376572a0 10.1016/S0028-3932(96)00070-X 10.1016/0306-4522(92)90271-3 10.1542/peds.95.6.860 10.1016/0006-8993(91)91041-X 10.1016/S0006-8993(99)01477-8 10.1001/archpsyc.1987.01800190080012 10.1097/00004583-199703000-00016 10.1192/bjp.164.2.165 10.1016/0006-3223(95)00653-2 10.1016/0091-3057(94)00273-L 10.1016/0020-7292(93)90271-W 10.1523/JNEUROSCI.12-09-03609.1992 10.1016/0361-9230(94)90246-1 10.1016/0014-2999(95)00306-6 10.1007/s002130050419 10.1203/00006450-199701000-00006 10.1016/0022-3956(87)90088-4 10.1523/JNEUROSCI.19-07-02834.1999 10.1073/pnas.83.24.9779 10.1523/JNEUROSCI.19-24-11049.1999 10.1523/JNEUROSCI.18-15-05901.1998 10.1016/S0166-4328(96)02251-6 10.1159/000089314 10.1177/000992289703600702 10.1016/S0166-4328(05)80078-6 10.1016/0361-9230(93)90312-Y 10.1016/0006-8993(95)01557-4 10.1111/j.1471-4159.1980.tb04625.x 10.1016/0006-8993(93)90655-7 10.1192/bjp.162.2.161 10.1177/0883073891006001091 10.1016/0006-8993(92)91639-V 10.1016/0014-2999(88)90122-7 10.1016/0006-8993(82)90857-5 10.1016/S0306-4522(97)00392-8 10.1016/0006-8993(81)90243-2 10.1016/0165-3806(83)90171-2 10.1016/S0006-3223(97)00507-6 10.1016/0166-4328(88)90010-1 10.1159/000182393 10.1016/S0306-4522(97)00370-9 10.1016/S0306-4522(96)00543-X 10.1016/0006-8993(95)01290-7 10.1016/0165-3806(85)90054-9 10.1126/science.283.5400.397 10.1016/0165-0173(90)90015-G 10.1016/0006-3223(94)00217-Q 10.1006/exnr.1997.6437 10.1016/0166-4328(83)90028-1 10.1073/pnas.93.3.1325 10.1176/ajp.148.11.1474 10.1016/0006-8993(79)90094-5 10.1111/j.1939-0025.1985.tb03433.x 10.1007/s002130050029 10.1016/0306-4522(94)00531-9 10.1002/cne.903130309 10.1016/0920-9964(93)90011-7 10.1016/0006-8993(90)91604-F 10.1016/0006-8993(94)90383-2 10.1002/(SICI)1098-2396(199707)26:3<225::AID-SYN4>3.0.CO;2-9 10.1111/j.1471-4159.1989.tb09224.x 10.1002/cne.903130308 10.1016/S0006-8993(99)01099-9 10.1038/sj.mp.4000290 10.1002/(SICI)1098-2396(19990601)32:3<187::AID-SYN5>3.0.CO;2-9 10.1016/S0306-4522(00)00002-6 10.1016/0378-3782(91)90044-4 |
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References | 2023041302454352000_20.14.5538.5 2023041302454352000_20.14.5538.6 2023041302454352000_20.14.5538.3 McEwen (2023041302454352000_20.14.5538.49) 1992; 37 2023041302454352000_20.14.5538.4 2023041302454352000_20.14.5538.9 2023041302454352000_20.14.5538.40 2023041302454352000_20.14.5538.8 2023041302454352000_20.14.5538.42 Poets (2023041302454352000_20.14.5538.58) 1995; 95 2023041302454352000_20.14.5538.44 2023041302454352000_20.14.5538.43 2023041302454352000_20.14.5538.1 2023041302454352000_20.14.5538.46 2023041302454352000_20.14.5538.2 2023041302454352000_20.14.5538.45 2023041302454352000_20.14.5538.48 2023041302454352000_20.14.5538.47 2023041302454352000_20.14.5538.39 2023041302454352000_20.14.5538.38 2023041302454352000_20.14.5538.51 2023041302454352000_20.14.5538.50 2023041302454352000_20.14.5538.53 2023041302454352000_20.14.5538.52 2023041302454352000_20.14.5538.11 2023041302454352000_20.14.5538.55 2023041302454352000_20.14.5538.10 Castellanos (2023041302454352000_20.14.5538.18) 1997; 37 2023041302454352000_20.14.5538.54 2023041302454352000_20.14.5538.13 2023041302454352000_20.14.5538.57 2023041302454352000_20.14.5538.12 2023041302454352000_20.14.5538.56 2023041302454352000_20.14.5538.15 2023041302454352000_20.14.5538.59 2023041302454352000_20.14.5538.14 Hershkowitz (2023041302454352000_20.14.5538.41) 1983; 283 2023041302454352000_20.14.5538.60 2023041302454352000_20.14.5538.62 2023041302454352000_20.14.5538.61 2023041302454352000_20.14.5538.20 2023041302454352000_20.14.5538.64 2023041302454352000_20.14.5538.63 2023041302454352000_20.14.5538.22 2023041302454352000_20.14.5538.66 2023041302454352000_20.14.5538.65 2023041302454352000_20.14.5538.24 2023041302454352000_20.14.5538.68 2023041302454352000_20.14.5538.67 2023041302454352000_20.14.5538.26 2023041302454352000_20.14.5538.25 2023041302454352000_20.14.5538.69 2023041302454352000_20.14.5538.17 2023041302454352000_20.14.5538.16 Dell'Anna (2023041302454352000_20.14.5538.21) 1991; 45 Boksa (2023041302454352000_20.14.5538.7) 1997; 41 2023041302454352000_20.14.5538.71 2023041302454352000_20.14.5538.70 2023041302454352000_20.14.5538.73 2023041302454352000_20.14.5538.72 2023041302454352000_20.14.5538.31 2023041302454352000_20.14.5538.75 2023041302454352000_20.14.5538.30 2023041302454352000_20.14.5538.74 Deutch (2023041302454352000_20.14.5538.23) 1992; 36 2023041302454352000_20.14.5538.33 2023041302454352000_20.14.5538.32 2023041302454352000_20.14.5538.76 2023041302454352000_20.14.5538.35 2023041302454352000_20.14.5538.34 2023041302454352000_20.14.5538.37 2023041302454352000_20.14.5538.36 2023041302454352000_20.14.5538.28 2023041302454352000_20.14.5538.27 2023041302454352000_20.14.5538.29 Cook (2023041302454352000_20.14.5538.19) 1995; 56 |
References_xml | – ident: 2023041302454352000_20.14.5538.61 doi: 10.1126/science.462179 – ident: 2023041302454352000_20.14.5538.22 doi: 10.1007/PL00005670 – ident: 2023041302454352000_20.14.5538.76 doi: 10.1038/376572a0 – ident: 2023041302454352000_20.14.5538.55 doi: 10.1016/S0028-3932(96)00070-X – ident: 2023041302454352000_20.14.5538.57 – ident: 2023041302454352000_20.14.5538.65 doi: 10.1016/0306-4522(92)90271-3 – volume: 95 start-page: 860 year: 1995 ident: 2023041302454352000_20.14.5538.58 article-title: Prolonged episodes of hypoxemia in preterm infants undetectable by cardiorespiratory monitors. publication-title: Pediatrics doi: 10.1542/peds.95.6.860 contributor: fullname: Poets – ident: 2023041302454352000_20.14.5538.6 doi: 10.1016/0006-8993(91)91041-X – ident: 2023041302454352000_20.14.5538.11 doi: 10.1016/S0006-8993(99)01477-8 – ident: 2023041302454352000_20.14.5538.74 doi: 10.1001/archpsyc.1987.01800190080012 – ident: 2023041302454352000_20.14.5538.17 doi: 10.1097/00004583-199703000-00016 – ident: 2023041302454352000_20.14.5538.36 doi: 10.1192/bjp.164.2.165 – ident: 2023041302454352000_20.14.5538.51 doi: 10.1016/0006-3223(95)00653-2 – ident: 2023041302454352000_20.14.5538.71 doi: 10.1016/0091-3057(94)00273-L – ident: 2023041302454352000_20.14.5538.37 doi: 10.1016/0020-7292(93)90271-W – ident: 2023041302454352000_20.14.5538.52 doi: 10.1523/JNEUROSCI.12-09-03609.1992 – ident: 2023041302454352000_20.14.5538.63 doi: 10.1016/0361-9230(94)90246-1 – volume: 56 start-page: 993 year: 1995 ident: 2023041302454352000_20.14.5538.19 article-title: Association of attention-deficit disorder and the dopamine transporter gene. publication-title: Am J Human Genet contributor: fullname: Cook – ident: 2023041302454352000_20.14.5538.3 doi: 10.1016/0014-2999(95)00306-6 – ident: 2023041302454352000_20.14.5538.9 doi: 10.1007/s002130050419 – volume: 41 start-page: 34 year: 1997 ident: 2023041302454352000_20.14.5538.7 article-title: Early developmental profiles of plasma corticosterone are altered by birth condition in the rat: a comparison of vaginal birth, Cesarean section, and Cesarean section with added anoxia. publication-title: Pediat Res doi: 10.1203/00006450-199701000-00006 contributor: fullname: Boksa – ident: 2023041302454352000_20.14.5538.46 doi: 10.1016/0022-3956(87)90088-4 – volume: 36 start-page: 61 year: 1992 ident: 2023041302454352000_20.14.5538.23 article-title: The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia. publication-title: J Neural Transm Suppl contributor: fullname: Deutch – ident: 2023041302454352000_20.14.5538.31 – ident: 2023041302454352000_20.14.5538.69 doi: 10.1523/JNEUROSCI.19-07-02834.1999 – ident: 2023041302454352000_20.14.5538.38 doi: 10.1073/pnas.83.24.9779 – ident: 2023041302454352000_20.14.5538.15 doi: 10.1523/JNEUROSCI.19-24-11049.1999 – ident: 2023041302454352000_20.14.5538.28 doi: 10.1523/JNEUROSCI.18-15-05901.1998 – ident: 2023041302454352000_20.14.5538.4 doi: 10.1016/S0166-4328(96)02251-6 – ident: 2023041302454352000_20.14.5538.8 doi: 10.1159/000089314 – volume: 37 start-page: 381 year: 1997 ident: 2023041302454352000_20.14.5538.18 article-title: Toward a pathophysiology of attention-deficit/hyperactivity disorder. publication-title: Clin Pediat doi: 10.1177/000992289703600702 contributor: fullname: Castellanos – volume: 45 start-page: 125 year: 1991 ident: 2023041302454352000_20.14.5538.21 article-title: Neonatal anoxia induces transitory hyperactivity, permanent spatial memory deficits and CA1 cell density reduction in developing rats. publication-title: Behav Brain Res doi: 10.1016/S0166-4328(05)80078-6 contributor: fullname: Dell'Anna – ident: 2023041302454352000_20.14.5538.2 doi: 10.1016/0361-9230(93)90312-Y – ident: 2023041302454352000_20.14.5538.25 doi: 10.1016/0006-8993(95)01557-4 – ident: 2023041302454352000_20.14.5538.29 – ident: 2023041302454352000_20.14.5538.42 – ident: 2023041302454352000_20.14.5538.60 doi: 10.1111/j.1471-4159.1980.tb04625.x – ident: 2023041302454352000_20.14.5538.13 doi: 10.1016/0006-8993(93)90655-7 – ident: 2023041302454352000_20.14.5538.56 doi: 10.1192/bjp.162.2.161 – ident: 2023041302454352000_20.14.5538.40 doi: 10.1177/0883073891006001091 – ident: 2023041302454352000_20.14.5538.24 doi: 10.1016/0006-8993(92)91639-V – ident: 2023041302454352000_20.14.5538.73 doi: 10.1016/0014-2999(88)90122-7 – ident: 2023041302454352000_20.14.5538.45 doi: 10.1016/0006-8993(82)90857-5 – ident: 2023041302454352000_20.14.5538.59 doi: 10.1016/S0306-4522(97)00392-8 – ident: 2023041302454352000_20.14.5538.62 doi: 10.1016/0006-8993(81)90243-2 – volume: 283 start-page: 147 year: 1983 ident: 2023041302454352000_20.14.5538.41 article-title: The effects of postnatal anoxia on behavior and on the muscarinic and beta-adrenergic receptors in the hippocampus of the developing rat. publication-title: Brain Res doi: 10.1016/0165-3806(83)90171-2 contributor: fullname: Hershkowitz – ident: 2023041302454352000_20.14.5538.44 doi: 10.1016/S0006-3223(97)00507-6 – ident: 2023041302454352000_20.14.5538.67 doi: 10.1016/0166-4328(88)90010-1 – volume: 37 start-page: 1 year: 1992 ident: 2023041302454352000_20.14.5538.49 article-title: Steroid hormones: effect on brain development and function. publication-title: Hormone Res doi: 10.1159/000182393 contributor: fullname: McEwen – ident: 2023041302454352000_20.14.5538.68 doi: 10.1016/S0306-4522(97)00370-9 – ident: 2023041302454352000_20.14.5538.10 doi: 10.1016/S0306-4522(96)00543-X – ident: 2023041302454352000_20.14.5538.14 doi: 10.1016/0006-8993(95)01290-7 – ident: 2023041302454352000_20.14.5538.50 doi: 10.1016/0165-3806(85)90054-9 – ident: 2023041302454352000_20.14.5538.30 doi: 10.1126/science.283.5400.397 – ident: 2023041302454352000_20.14.5538.75 doi: 10.1016/0165-0173(90)90015-G – ident: 2023041302454352000_20.14.5538.16 doi: 10.1016/0006-3223(94)00217-Q – ident: 2023041302454352000_20.14.5538.27 doi: 10.1006/exnr.1997.6437 – ident: 2023041302454352000_20.14.5538.66 doi: 10.1016/0166-4328(83)90028-1 – ident: 2023041302454352000_20.14.5538.53 doi: 10.1073/pnas.93.3.1325 – ident: 2023041302454352000_20.14.5538.20 doi: 10.1176/ajp.148.11.1474 – ident: 2023041302454352000_20.14.5538.47 doi: 10.1016/0006-8993(79)90094-5 – ident: 2023041302454352000_20.14.5538.39 doi: 10.1111/j.1939-0025.1985.tb03433.x – ident: 2023041302454352000_20.14.5538.43 doi: 10.1007/s002130050029 – ident: 2023041302454352000_20.14.5538.70 doi: 10.1016/0306-4522(94)00531-9 – ident: 2023041302454352000_20.14.5538.35 doi: 10.1002/cne.903130309 – ident: 2023041302454352000_20.14.5538.72 doi: 10.1016/0920-9964(93)90011-7 – ident: 2023041302454352000_20.14.5538.48 doi: 10.1016/0006-8993(90)91604-F – ident: 2023041302454352000_20.14.5538.33 doi: 10.1016/0006-8993(94)90383-2 – ident: 2023041302454352000_20.14.5538.26 doi: 10.1002/(SICI)1098-2396(199707)26:3<225::AID-SYN4>3.0.CO;2-9 – ident: 2023041302454352000_20.14.5538.1 doi: 10.1111/j.1471-4159.1989.tb09224.x – ident: 2023041302454352000_20.14.5538.34 doi: 10.1002/cne.903130308 – ident: 2023041302454352000_20.14.5538.54 doi: 10.1016/S0006-8993(99)01099-9 – ident: 2023041302454352000_20.14.5538.32 doi: 10.1038/sj.mp.4000290 – ident: 2023041302454352000_20.14.5538.5 doi: 10.1002/(SICI)1098-2396(19990601)32:3<187::AID-SYN5>3.0.CO;2-9 – ident: 2023041302454352000_20.14.5538.12 doi: 10.1016/S0306-4522(00)00002-6 – ident: 2023041302454352000_20.14.5538.64 doi: 10.1016/0378-3782(91)90044-4 |
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Snippet | Obstetric complications involving anoxia or prolonged hypoxia are suspected to increase the risk for such mental disorders as schizophrenia and attention... |
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SubjectTerms | Analysis of Variance Animals Carrier Proteins - metabolism Cesarean Section Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins Female Fetal Hypoxia - physiopathology Functional Laterality Male Membrane Glycoproteins Membrane Transport Proteins Motor Activity Nerve Tissue Proteins Prefrontal Cortex - physiopathology Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Sprague-Dawley Receptors, Dopamine - metabolism |
Title | Perinatal Distress Leads to Lateralized Medial Prefrontal Cortical Dopamine Hypofunction in Adult Rats |
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