Conversion of biliary system to pancreatic tissue in Hes1 -deficient mice

• Published in: Nature genetics Vol. 36; no. 1; pp. 83 - 87
• Main Authors: Sumazaki, Ryo, Shiojiri, Nobuyoshi, Isoyama, Shigemi, Masu, Masayuki, Keino-Masu, Kazuko, Osawa, Mitsujiro, Nakauchi, Hiromitsu, Kageyama, Ryoichiro, Matsui, Akira
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01.01.2004
• Subjects: Animals; Basic Helix-Loop-Helix Transcription Factors; Biliary duct; Biliary tract; Biliary Tract - embryology; Biological and medical sciences; Cell Differentiation; Fundamental and applied biological sciences. Psychology; Gallbladder - embryology; Gene Expression Regulation, Developmental; Gene mutations; Genetic aspects; Genetics of eukaryotes. Biological and molecular evolution; Hes-1 gene; Homeodomain Proteins - genetics; Identification and classification; Mammals; Mice; Mice, Mutant Strains; Morphogenesis; Mutation; Nerve Tissue Proteins - genetics; Neurog3 gene; Pancreas - embryology; Physiological aspects; Polymerase chain reaction; Signal Transduction; Transcription Factor HES-1; Transcription Factors - genetics; Japan; Tissue; Vertebrata; Mammalia; Mouse; Rodentia

The biliary system, pancreas and liver all develop from the nearby foregut at almost the same time in mammals. The molecular mechanisms that determine the identity of each organ in this complex area are unknown. Hes1 encodes the basic helix-loop-helix protein Hes1 (ref. 1), which represses positive...