Role of nasal nitric oxide in the resolution of experimental rhinovirus infection

• Published in: Journal of Allergy and Clinical Immunology Vol. 113; no. 4; pp. 697 - 702
• Main Authors: Sanders, Scherer P, Proud, David, Permutt, Solbert, Siekierski, Edward S, Yachechko, Robin, Liu, Mark C
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.04.2004; Elsevier; Elsevier Limited
• Subjects: asthma; Bacterial infections; Bioassays; Biological and medical sciences; Colds; common cold; Common Cold - metabolism; Common Cold - pathology; Common Cold - physiopathology; Cytokines; Cytotoxicity; epithelial cells; Exhalation; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; host defense; Human rhinovirus; Human subjects; Humans; Hypotheses; Immunopathology; inducible nitric oxide synthase; Infections; Male; Medical sciences; Nasal Cavity - metabolism; Nasal Cavity - pathology; Nitric Oxide; Nitric Oxide Synthase - genetics; Nitric Oxide Synthase Type II; Osmolar Concentration; Regression analysis; Respiratory System - metabolism; Rhinovirus; RNA, Messenger - metabolism; Studies; Viral infections; NO; nitric oxide; NOS; host defense; eNO; epithelial cells; asthma; TCID50; HRV; Rhinovirus; common cold; inducible nitric oxide synthase; Nose disease; Picornaviridae; Immunity; Immunology; Bronchus disease; ENT disease; Obstructive pulmonary disease; EC 1.14.13.39; Lung disease; Immunopathology; Respiratory disease; Enzyme; Common cold; Nitric-oxide synthase; Asthma; Virus; Infection; Viral disease; Nitric oxide; Epithelial cell; Oxidoreductases

Human rhinovirus (HRV) infections are associated with exacerbations of asthma, chronic obstructive pulmonary disease, and sinusitis. Nitric oxide (NO) might play an important role in host defense through its potent antiviral properties. Previous studies have shown that HRV infection in human subject...