Defining three dimensional chromatin structures of pediatric and adolescent B cells using primary B cell and EBV-immortalized B cell reference genomes - Jiang, Kaiyu; Fu, Yao; Kelly, Jennifer A.; Gaffney, Patrick M.; Holmes, Lucy C.; Jarvis, James N. (BMC medical genomics, 2025)
Keywords: Adolescent; Arthritis; Arthritis, Juvenile - genetics; Autoimmune diseases; B cells; B-Lymphocytes - metabolism; Beta cells; CCCTC-Binding Factor - metabolism; Cell lines; Child; Chromatin; Chromatin - chemistry; Chromatin - genetics; Chromatin accessibility; Chromatin conformation; Datasets; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - genetics; DNA methylation; Epstein-Barr virus; Female; Genes; Genetic aspects; Genetic research; Genome, Human; Genomes; Genomics; Haplotypes; Health aspects; Herpesvirus 4, Human - genetics; Herpesvirus 4, Human - physiology; Human subjects; Humans; Immune system; Juvenile arthritis; Lupus Erythematosus, Systemic - genetics; Pediatric autoimmune disease; Pediatrics; Physiological aspects; Systemic lupus; Systemic lupus erythematosus; Teenagers; United States; United States--US; Chromatin accessibility; Chromatin conformation; Type 1 diabetes; Juvenile arthritis; Systemic lupus; B cells; Pediatric autoimmune disease