Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

• Published in: The Journal of experimental medicine Vol. 208; no. 2; pp. 261 - 271
• Main Authors: Chow, Andrew, Lucas, Daniel, Hidalgo, Andrés, Méndez-Ferrer, Simón, Hashimoto, Daigo, Scheiermann, Christoph, Battista, Michela, Leboeuf, Marylene, Prophete, Colette, van Rooijen, Nico, Tanaka, Masato, Merad, Miriam, Frenette, Paul S.
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 14.02.2011
• Subjects: Animals; Bone Marrow Cells - cytology; Bone Marrow Cells - metabolism; Chemokine CXCL12 - metabolism; Colony-Forming Units Assay; DNA Primers - genetics; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorescent Antibody Technique; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells - cytology; Homeostasis - immunology; Interleukin-10 - genetics; Macrophages - metabolism; Male; Membrane Glycoproteins - metabolism; Mesenchymal Stromal Cells - cytology; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes - metabolism; Polymerase Chain Reaction; Receptor Cross-Talk - immunology; Receptors, Immunologic - metabolism; Sialic Acid Binding Ig-like Lectin 1

Hematopoietic stem cells (HSCs) reside in specialized bone marrow (BM) niches regulated by the sympathetic nervous system (SNS). Here, we have examined whether mononuclear phagocytes modulate the HSC niche. We defined three populations of BM mononuclear phagocytes that include Gr-1hi monocytes (MOs)...