Baicalin ameliorates Mycoplasma gallisepticum-induced inflammatory injury via inhibiting STIM1-regulated ceramide accumulation in DF-1 cells

• Published in: Poultry science Vol. 102; no. 6; p. 102687
• Main Authors: Chen, Xueping, Ishfaq, Muhammad, Wang, Jian
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.06.2023; Elsevier
• Subjects: Animals; Apoptosis; baicalin; calcium; Calcium - metabolism; ceramide; Ceramides; Chickens - metabolism; endoplasmic reticulum stress; eukaryotic cells; homeostasis; IMMUNOLOGY, HEALTH AND DISEASE; Mycoplasma gallisepticum; Mycoplasma gallisepticum - physiology; oxidative stress; pathogenesis; poultry science; STIM1; Stromal Interaction Molecule 1 - metabolism; ceramide; STIM1; baicalin; endoplasmic reticulum stress; Mycoplasma gallisepticum

Mycoplasma gallisepticum (MG) is dependent on its host for many nutrients due to the loss of many important metabolic pathways. Ceramide is a sphingolipid that regulates multiple cellular processes in eukaryotic cell. Several studies highlighted the crucial role of ceramide on the pathogenesis of va...