Validity and clinical impact of glucose transporter 1 expression in colorectal cancer
There is no doubt that colorectal cancer (CRC) poses a major threat to public health worldwide, and despite improvement in managements, prognosis still remains an irritating question with no definite answer. Being a fundamental player in cancer metabolism, glucose transporter 1 (GLUT1) could be util...
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Published in | Saudi journal of gastroenterology Vol. 23; no. 6; pp. 348 - 356 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Medknow Publications and Media Pvt. Ltd
01.11.2017
Medknow Publications & Media Pvt. Ltd Medknow Publications & Media Pvt Ltd Wolters Kluwer Medknow Publications |
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Abstract | There is no doubt that colorectal cancer (CRC) poses a major threat to public health worldwide, and despite improvement in managements, prognosis still remains an irritating question with no definite answer. Being a fundamental player in cancer metabolism, glucose transporter 1 (GLUT1) could be utilized as a prognostic biomarker that could fuel development of new treatment strategies. The aim of this study was to assess the validity of GLUT1 expression as a prognostic biomarker and to elucidate to what extent it is immersed in poor clinical outcome among CRC patients.
GLUT1 expression in peripheral blood specimens was analyzed by quantitative real-time polymerase chain reaction in 47 CRC patients and 20 healthy controls.
There was significantly elevated GLUT1 expression in peripheral blood of CRC patients than in controls (P < 0.001). The cutoff value of 0.605 provided 98% sensitivity and 100% specificity. There were significantly higher values of GLUT1 expression in patients under 50 years (P = 0.003), performance status 2 (P = 0.009), stage IV (P < 0.001), and presence of metastasis (P < 0.001). GLUT1 expression showed nonsignificant association with overall survival (P = 0.068), while tumor stage (P = 0.01) and metastasis (P = 0.009) were significantly associated with lower overall survival.
GLUT1 is sensitive and specific marker for CRC. It is overexpressed in young age patients, poor performance status, and stage IV patients. Although this was not statistically significant, GLUT 1 showed higher expression level in patients with lesser survival. |
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AbstractList | Background/Aim: There is no doubt that colorectal cancer (CRC) poses a major threat to public health worldwide, and despite improvement in managements, prognosis still remains an irritating question with no definite answer. Being a fundamental player in cancer metabolism, glucose transporter 1 (GLUT1) could be utilized as a prognostic biomarker that could fuel development of new treatment strategies. The aim of this study was to assess the validity of GLUT1 expression as a prognostic biomarker and to elucidate to what extent it is immersed in poor clinical outcome among CRC patients. Patients and Methods: GLUT1 expression in peripheral blood specimens was analyzed by quantitative real-time polymerase chain reaction in 47 CRC patients and 20 healthy controls. Results: There was significantly elevated GLUT1 expression in peripheral blood of CRC patients than in controls (P < 0.001). The cutoff value of 0.605 provided 98% sensitivity and 100% specificity. There were significantly higher values of GLUT1 expression in patients under 50 years (P = 0.003), performance status 2 (P = 0.009), stage IV (P < 0.001), and presence of metastasis (P < 0.001). GLUT1 expression showed nonsignificant association with overall survival (P = 0.068), while tumor stage (P = 0.01) and metastasis (P = 0.009) were significantly associated with lower overall survival. Conclusion: GLUT1 is sensitive and specific marker for CRC. It is overexpressed in young age patients, poor performance status, and stage IV patients. Although this was not statistically significant, GLUT 1 showed higher expression level in patients with lesser survival. BACKGROUND/AIMThere is no doubt that colorectal cancer (CRC) poses a major threat to public health worldwide, and despite improvement in managements, prognosis still remains an irritating question with no definite answer. Being a fundamental player in cancer metabolism, glucose transporter 1 (GLUT1) could be utilized as a prognostic biomarker that could fuel development of new treatment strategies. The aim of this study was to assess the validity of GLUT1 expression as a prognostic biomarker and to elucidate to what extent it is immersed in poor clinical outcome among CRC patients.PATIENTS AND METHODSGLUT1 expression in peripheral blood specimens was analyzed by quantitative real-time polymerase chain reaction in 47 CRC patients and 20 healthy controls.RESULTSThere was significantly elevated GLUT1 expression in peripheral blood of CRC patients than in controls (P < 0.001). The cutoff value of 0.605 provided 98% sensitivity and 100% specificity. There were significantly higher values of GLUT1 expression in patients under 50 years (P = 0.003), performance status 2 (P = 0.009), stage IV (P < 0.001), and presence of metastasis (P < 0.001). GLUT1 expression showed nonsignificant association with overall survival (P = 0.068), while tumor stage (P = 0.01) and metastasis (P = 0.009) were significantly associated with lower overall survival.CONCLUSIONGLUT1 is sensitive and specific marker for CRC. It is overexpressed in young age patients, poor performance status, and stage IV patients. Although this was not statistically significant, GLUT 1 showed higher expression level in patients with lesser survival. There is no doubt that colorectal cancer (CRC) poses a major threat to public health worldwide, and despite improvement in managements, prognosis still remains an irritating question with no definite answer. Being a fundamental player in cancer metabolism, glucose transporter 1 (GLUT1) could be utilized as a prognostic biomarker that could fuel development of new treatment strategies. The aim of this study was to assess the validity of GLUT1 expression as a prognostic biomarker and to elucidate to what extent it is immersed in poor clinical outcome among CRC patients. GLUT1 expression in peripheral blood specimens was analyzed by quantitative real-time polymerase chain reaction in 47 CRC patients and 20 healthy controls. There was significantly elevated GLUT1 expression in peripheral blood of CRC patients than in controls (P < 0.001). The cutoff value of 0.605 provided 98% sensitivity and 100% specificity. There were significantly higher values of GLUT1 expression in patients under 50 years (P = 0.003), performance status 2 (P = 0.009), stage IV (P < 0.001), and presence of metastasis (P < 0.001). GLUT1 expression showed nonsignificant association with overall survival (P = 0.068), while tumor stage (P = 0.01) and metastasis (P = 0.009) were significantly associated with lower overall survival. GLUT1 is sensitive and specific marker for CRC. It is overexpressed in young age patients, poor performance status, and stage IV patients. Although this was not statistically significant, GLUT 1 showed higher expression level in patients with lesser survival. |
Audience | Academic |
Author | El-Din Habib, Mona Salah Soliman, Shimaa El-Shafey Kasemy, Zienab A GabAllah, Ghada M K Gohar, Suzy F |
AuthorAffiliation | Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt 1 Department of Public Health and Community Medicine, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt 2 Department of Clinical Oncology, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt |
AuthorAffiliation_xml | – name: Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt – name: 1 Department of Public Health and Community Medicine, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt – name: 2 Department of Clinical Oncology, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt |
Author_xml | – sequence: 1 givenname: Ghada M K surname: GabAllah fullname: GabAllah, Ghada M K organization: Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt – sequence: 2 givenname: Mona Salah surname: El-Din Habib fullname: El-Din Habib, Mona Salah organization: Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt – sequence: 3 givenname: Shimaa El-Shafey surname: Soliman fullname: Soliman, Shimaa El-Shafey organization: Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt – sequence: 4 givenname: Zienab A surname: Kasemy fullname: Kasemy, Zienab A organization: Department of Public Health and Community Medicine, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt – sequence: 5 givenname: Suzy F surname: Gohar fullname: Gohar, Suzy F organization: Department of Clinical Oncology, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt |
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CitedBy_id | crossref_primary_10_1016_j_mbs_2023_109044 crossref_primary_10_1016_j_prp_2023_154756 crossref_primary_10_3390_cancers12102968 crossref_primary_10_2174_1871520620666200318094618 |
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Snippet | There is no doubt that colorectal cancer (CRC) poses a major threat to public health worldwide, and despite improvement in managements, prognosis still remains... Background/Aim: There is no doubt that colorectal cancer (CRC) poses a major threat to public health worldwide, and despite improvement in managements,... BACKGROUND/AIMThere is no doubt that colorectal cancer (CRC) poses a major threat to public health worldwide, and despite improvement in managements, prognosis... |
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SubjectTerms | Age Biochemistry Biomarkers Colonoscopy Colorectal cancer Development and progression Gene expression Genetic aspects Glucose metabolism glucose transporter 1 Health aspects Hypoxia Medicine Metabolism Original Patient compliance Physiological aspects Prognosis Proteomics Public health real-time polymerase chain reaction Transport proteins Tumors |
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Title | Validity and clinical impact of glucose transporter 1 expression in colorectal cancer |
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