STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion

• Published in: Pflügers Archiv Vol. 465; no. 9; pp. 1249 - 1260
• Main Authors: Motiani, Rajender K., Hyzinski-García, María C., Zhang, Xuexin, Henkel, Matthew M., Abdullaev, Iskandar F., Kuo, Yu-Hung, Matrougui, Khalid, Mongin, Alexander A., Trebak, Mohamed
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2013; Springer Nature B.V
• Subjects: Action Potentials; Astrocytes - metabolism; Biomedical and Life Sciences; Biomedicine; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Calcium - metabolism; Calcium Channels - genetics; Calcium Channels - metabolism; Calcium Signaling; Cell Biology; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glioblastoma - metabolism; Glioblastoma - pathology; Human Physiology; Humans; Ion Channels; Membrane Proteins - genetics; Membrane Proteins - metabolism; Molecular Medicine; Neoplasm Invasiveness; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Neurosciences; ORAI1 Protein; Receptors; Receptors and Transporters; Stromal Interaction Molecule 1; Transcription, Genetic; Up-Regulation; Calcium signaling; Orai1; Cancer invasion; Store operated calcium entry; STIM1; Glioblastoma multiforme

The Ca 2+ sensor stromal interacting molecule 1 (STIM1) and the Ca 2+ channel Orai1 mediate the ubiquitous store-operated Ca 2+ entry (SOCE) pathway activated by depletion of internal Ca 2+ stores and mediated through the highly Ca 2+ -selective, Ca 2+ release-activated Ca 2+ (CRAC) current. Further...