Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects - Rametta, R; Mozzi, E; Dongiovanni, P; Motta, B M; Milano, M; Roviaro, G; Fargion, S; Valenti, L (International Journal of Obesity, 2013)
Keywords: 631/443/319/2723; 631/80/86/2367; 692/699/1503/1607/2750; 692/699/2743/393; Adult; Aged; Biological and medical sciences; Blotting, Western; Body mass index; Cellular signal transduction; Cholesterol; Diabetes; Epidemiology; Fatty Liver - genetics; Fatty Liver - metabolism; Fatty Liver - physiopathology; Female; Forkhead Box Protein O1; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal surgery; Gene Expression; Glucose; Health Promotion and Disease Prevention; High density lipoprotein; Histology; Humans; Insulin; Insulin Receptor Substrate Proteins - genetics; Insulin Receptor Substrate Proteins - metabolism; Insulin resistance; Insulin Resistance - genetics; Internal Medicine; Italy; Kinases; Lipid Metabolism; Lipids; Lipogenesis; Liver; Liver - metabolism; Liver diseases; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic disorders; Metabolic syndrome; Middle Aged; Obesity; Obesity, Morbid - genetics; Obesity, Morbid - metabolism; Obesity, Morbid - physiopathology; original-article; Other diseases. Semiology; Oxidative Stress; Pathophysiology; Phosphorylation; Physiological aspects; Proteins; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Public Health; Real-Time Polymerase Chain Reaction; Receptors; Retrospective Studies; RNA, Messenger; Signal Transduction; Sterol Regulatory Element Binding Protein 1 - genetics; Sterol Regulatory Element Binding Protein 1 - metabolism; Sterols; Substrates; Italy; insulin receptor substrate 2; nonalcoholic fatty liver disease; lipogenesis; insulin resistance; steatosis; glucokinase; Endocrinopathy; Pancreatic hormone; Hepatic disease; Lipids; Association; Lipogenesis; Nutritional status; Human; Obesity; Nutrition; Enzyme; Transferases; Nutrition disorder; Metabolic diseases; Gene expression; Metabolism; Insulin; Steatosis; Target tissue resistance