The investigation of apoptosis-related genes in periodontitis

• Published in: BMC research notes Vol. 18; no. 1; pp. 211 - 8
• Main Authors: Sayad, Arezou, Hashemian, Fatemeh, Gholami, Leila, Jamali, Masoud, Badrlou, Elham, Sadeghpour, Saba, Nazer, Naghme, Khalilian, Sheyda, Ghafouri-Fard, Soudeh
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.05.2025; BioMed Central; BMC
• Subjects: Adult; Apoptosis; Apoptosis - genetics; B-Cell CLL/Lymphoma 2; Bcl-2 protein; Case-Control Studies; Caspase 8; Caspase 8 - blood; Caspase 8 - genetics; Caspase 8 - metabolism; Caspase2; Chronic illnesses; Development and progression; Efficiency; Female; Females; Gene expression; Generalized linear models; Genes; Genetic aspects; Gingiva - metabolism; Gingiva - pathology; Gum disease; Health aspects; HULC; Humans; Male; Males; Microorganisms; Middle Aged; Periodontitis; Periodontitis - blood; Periodontitis - genetics; Periodontitis - metabolism; Periodontitis - pathology; Peripheral blood; Proteins; Proto-Oncogene Proteins c-bcl-2 - blood; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; Pvt1; Research Note; Risk factors; RNA, Long Noncoding - blood; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Statistical analysis; Transplants & implants; Iran; South Korea; Taiwan; Caspase2; Caspase 8; Periodontitis; Pvt1; HULC; B-Cell CLL/Lymphoma 2

This study aims at determination of the roles of five apoptosis-related genes, namely CASP2, CASP8, BCL2, HULC and PVT1 in the pathoetiology of periodontitis via measurement of their expressions in both peripheral blood and tissues of affected persons. CASP2 was over-expressed in gingiva of patients...