Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage

• Published in: Scientific reports Vol. 14; no. 1; pp. 682 - 12
• Main Authors: Zheng, Xi, Toyama, Takashi, Siu, Stephanie, Kaneko, Takayuki, Sugiura, Hikari, Yamashita, Shota, Shimoda, Yoshiteru, Kanamori, Masayuki, Arisawa, Kotoko, Endo, Hidenori, Saito, Yoshiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.01.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/80; 692/700; Antitumor agents; Astrocytes; Autocrine signalling; Brain cancer; Brain tumors; Cell death; Chemotherapy; Drug resistance; Ferroptosis; Glioblastoma; Glutathione peroxidase; Humanities and Social Sciences; multidisciplinary; Paracrine signalling; Science; Science (multidisciplinary); Selenite; Selenium; Therapeutic targets

Glioblastoma (GBM) is one of the most aggressive and deadly brain tumors; however, its current therapeutic strategies are limited. Selenoprotein P (SeP; SELENOP, encoded by the SELENOP gene) is a unique selenium-containing protein that exhibits high expression levels in astroglia. SeP is thought to...