TFAP2A upregulates FAM83A to suppress ferroptosis and diminish cisplatin sensitivity in non-small cell lung cancer

• Published in: Cell division Vol. 20; no. 1; pp. 19 - 15
• Main Authors: Sun, Qi, Qu, Weifeng, Wang, Ye, Yang, Kejia, Weng, Yuan
• Format: Journal Article
• Language: English
• Published: England BioMed Central 11.07.2025; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; AP-2 protein; Cell growth; Cell migration; Chemotherapy; Cholecystokinin; Chromatin; Cisplatin; Drug resistance; FAM83A; Ferroptosis; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Invasiveness; Lung cancer; Metastasis; Mortality; Motility; Non-small cell lung carcinoma; NSCLC; Proteins; Small cell lung carcinoma; Transcription factor; Transcription factors; Tumorigenesis; Wnt protein; Wound healing; Xenografts; β-Catenin; Ferroptosis; NSCLC; Drug resistance; Transcription factor; FAM83A

FAM83A plays a significant role in the development of non-small cell lung cancer (NSCLC). This study elucidated the biological role of FAM83A in ferroptosis and cisplatin (DDP) sensitivity in NSCLC cells. The expression patterns of FAM83A and TFAP2A were analyzed by bioinformatic analysis. mRNA and...