Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone

• Published in: PloS one Vol. 4; no. 4; p. e5275
• Main Authors: Mohammad, Khalid S, Chen, Carol G, Balooch, Guive, Stebbins, Elizabeth, McKenna, C Ryan, Davis, Holly, Niewolna, Maria, Peng, Xiang Hong, Nguyen, Daniel H N, Ionova-Martin, Sophi S, Bracey, John W, Hogue, William R, Wong, Darren H, Ritchie, Robert O, Suva, Larry J, Derynck, Rik, Guise, Theresa A, Alliston, Tamara
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.04.2009; Public Library of Science (PLoS)
• Subjects: Animals; Architecture; BASIC BIOLOGICAL SCIENCES; Biocompatibility; Biomedical materials; Bone (trabecular); Bone and Bones - anatomy & histology; Bone and Bones - cytology; Bone and Bones - metabolism; Bone Density - drug effects; Bone Development - drug effects; bone fracture; Bone growth; Bone marrow; Bone mass; Bone matrix; Bone Matrix - metabolism; Bone resorption; Bone Resorption - metabolism; Bone strength; Bones; Calcification, Physiologic - drug effects; Cancellous bone; Cbfa-1 protein; Cell Biology/Cell Signaling; Cell Differentiation - drug effects; Core Binding Factor Alpha 1 Subunit - metabolism; Diabetes and Endocrinology/Bone and Mineral Metabolism; Differentiation; Electric power; Endocrinology; Extracellular matrix; Female; femur; Fracture toughness; Fragility; Genetic engineering; Growth factors; Hormones; Inhibition; Inhibitors; Internal medicine; Laboratories; Male; Materials science; Mechanical properties; Medicine; Mice; Mice, Inbred C57BL; osteoblast differentiation; Osteoblastogenesis; Osteoblasts; Osteoblasts - metabolism; Osteoclastogenesis; Osteoclasts; Osteoclasts - metabolism; Osteogenesis; Pharmacology; Physiology/Muscle and Connective Tissue; Protein Kinase Inhibitors - pharmacology; Protein-Serine-Threonine Kinases - antagonists & inhibitors; Receptor, EphB4 - metabolism; Receptors, Transforming Growth Factor beta - antagonists & inhibitors; signal inhibition; Skeleton; Studies; Surgery; Test methods; Transforming Growth Factor beta - metabolism; Vertebrae; San Francisco California; California; United States > US; Arkansas; Virginia

During development, growth factors and hormones cooperate to establish the unique sizes, shapes and material properties of individual bones. Among these, TGF-beta has been shown to developmentally regulate bone mass and bone matrix properties. However, the mechanisms that control postnatal skeletal...