A polysaccharide from Sargassum fusiforme protects against immunosuppression in cyclophosphamide-treated mice

• Published in: Carbohydrate polymers Vol. 90; no. 2; pp. 1114 - 1119
• Main Authors: Chen, Xiaoming, Nie, Wenjian, Fan, Sairong, Zhang, Junfeng, Wang, Yanxing, Lu, Jianxin, Jin, Liqin
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.10.2012; Elsevier
• Subjects: Animals; anion exchange; Applied sciences; Biological and medical sciences; Carbohydrates; Cells, Cultured; Cellulose; Chromatography; Cyclophosphamide - antagonists & inhibitors; Cyclophosphamide - pharmacology; Cytoprotection - drug effects; Cytoprotection - immunology; D-Galactose; Exact sciences and technology; Filtration; Food industry; galactose; gel chromatography; Immune Tolerance - drug effects; Immunomodulators; Immunomodulatory; Immunostimulants; Immunosuppession; Immunosuppression; Immunosuppressive Agents - antagonists & inhibitors; Immunosuppressive Agents - pharmacology; interferon-gamma; Interleukin 2; Interleukin 6; Kidney - drug effects; Liver - drug effects; Lymphocytes; Macrophages; Macrophages, Peritoneal - drug effects; Macrophages, Peritoneal - physiology; Mannose; Medical sciences; Mice; Mice, Inbred ICR; Molecular weight; Natural polymers; Peritoneum; Phagocytes; pharmaceutical industry; Pharmaceuticals; Pharmacology. Drug treatments; Physicochemistry of polymers; Polysaccharide; Polysaccharides; Polysaccharides - isolation & purification; Polysaccharides - pharmacology; Sargassum - chemistry; Sargassum fusiforme; secretion; Spleen; Spleen - drug effects; Starch and polysaccharides; therapeutics; tumor necrosis factor-alpha; Sargassum fusiforme; Immunomodulatory; Immunosuppession; Polysaccharide; Cell proliferation; Molecular structure; Chemical isolation; Splenocyte; Solvent extraction; Algae; Rodentia; Experimental study; In vitro; Biological activity; Water soluble compound; In vivo; Vertebrata; Immunosuppression; Immunostimulant agent; Mammalia; Mouse; Animal; Oside polymer; Phagocytosis; Macrophage

► A water-soluble polysaccharide (SFPS) was isolated and purified from Sargassum fusiforme. ► Structural characterization of SFPS was investigated. ► SFPS stimulated proliferation and cytokines secretion of murine splenic lymphocytes. ► SFPS markedly increased the phagocytic rates and cytokines secr...