CanASM: a comprehensive database for genome-wide allele-specific DNA methylation identification and annotation in cancer

• Published in: BMC genomics Vol. 26; no. 1; pp. 648 - 14
• Main Authors: Zhao, Jianmei, Zhao, Zeyu, Li, Hongfei, Yu, Haojie, Lin, Hao, Chen, Hanqi, Li, Xuecang, Liu, Di, Wang, Yiming, Wang, Guohua
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.07.2025; BioMed Central; BMC
• Subjects: Alleles; Annotations; Anopheles; Bioinformatics; Biomarkers; Bisulfite; Browsing; Cancer; CpG islands; Databases, Genetic; Datasets; Deoxyribonucleic acid; DNA; DNA Methylation; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Gene regulation; Genes; Genetic aspects; Genetic diversity; Genetic research; Genetic transcription; Genome, Human; Genomes; Genomics; Health aspects; Humans; Methylation; Molecular Sequence Annotation; Neoplasms - genetics; Nucleotides; Oncology, Experimental; Physiological aspects; Polymorphism, Single Nucleotide; Regulatory sequences; Single nucleotide polymorphisms; Single nucleotide variation; Single-nucleotide polymorphism; Software; Sulfites; Tumorigenesis; China; DNA methylation; Single nucleotide variation; Bioinformatics; Gene regulation

Allele-specific DNA methylation (ASM) provides critical insights into the complex genetic and epigenetic mechanisms regulating gene transcription. Emerging evidence suggests that ASM is particularly enriched in gene enhancer regions, and recent studies have demonstrated that ASM is increased in canc...