Mitochondrial electron transport chain, ROS generation and uncoupling (Review)

• Published in: International journal of molecular medicine Vol. 44; no. 1; pp. 3 - 15
• Main Authors: Zhao, Ru‑Zhou, Jiang, Shuai, Zhang, Lin, Yu, Zhi‑Bin
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.07.2019; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Alzheimer's disease; Autophagy; Binding sites; Cell death; Cells (Biology); Cytochrome; Cytochrome b; Cytochrome c; Diabetes; Electron transport; HIV; Human immunodeficiency virus; Hypertension; Kinases; Oxidation; Oxidative stress; Pathology; Physiological aspects; Proteins; Protons; Reactive oxygen species; Sulfur; Tumor necrosis factor-TNF

The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as well as the electron transporters ubiquinone and cytochrome c. There are two electron transport pathways in the ETC: Complex I/III/IV, with NADH as the substrate and complex II/III/IV, with succinic acid as the su...