The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: A differential role of unfolded protein response (UPR) signaling proteins

• Published in: The international journal of biochemistry & cell biology Vol. 45; no. 2; pp. 438 - 447
• Main Authors: Lakshmanan, Arun Prasath, Harima, Meilei, Suzuki, Kenji, Soetikno, Vivian, Nagata, Masaki, Nakamura, Takashi, Takahashi, Toshihiro, Sone, Hirohito, Kawachi, Hiroshi, Watanabe, Kenichi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.02.2013
• Subjects: Activating Transcription Factor 6 - metabolism; Activation; animal disease models; Animals; Apoptosis; ATF6; blood glucose; cardiomyopathy; caspase-7; cytochrome c; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Diabetic Cardiomyopathies - metabolism; Diabetic Cardiomyopathies - pathology; Endoplasmic reticulum; Endoplasmic Reticulum Stress; ERS; genetically modified organisms; Glucose; glucose transporters; hyperglycemia; Hyperglycemia - metabolism; insulin; Intracellular Signaling Peptides and Proteins - metabolism; IRE-1α-XBP1 pathway; Lipids; lipogenesis; Male; MAP Kinase Signaling System; Metabolism; myocardium; Myocardium - metabolism; Myocardium - pathology; noninsulin-dependent diabetes mellitus; Oxidative Stress; Pathways; PERK-CHOP/GADD153 axis; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Protein Processing, Post-Translational; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Spontaneous Diabetic Torii; Unfolded Protein Response; JNK; ERS; PERK; PERK-CHOP/GADD153 axis; HDL; SD; BW; CPT1; LDL; UPR; IRE-1α-XBP1 pathway; SDT; XBP1; IRE-1α; GRP78; TRAF2; ER; GRP94; TC; eIF2α; TG; Spontaneous Diabetic Torii; AMPK; CHOP/GADD153; GLUT4; ATF6

[Display omitted] ► The PERK and ATF6 pathway play dominant roles for ER stress-mediated diabetic cardiomyopathy in non-obese type 2 DM. ► IRE-1α-XBP1 was not involved in the ER stress-mediated diabetic cardiomyopathy in non-obese type 2 DM. ► Differential regulation of UPR might have differential r...