Protective role of polyphenol extract from highland barley against cisplatin-induced renal toxicity and mitochondrial damage in rats

• Published in: FOOD SCIENCE AND TECHNOLOGY RESEARCH Vol. 29; no. 1; pp. 35 - 45
• Main Authors: Liu, Yunfan, Zhai, Jiazhou, Qin, Fei, Gao, Liping, She, Yongxin, Wang, Mengqiang
• Format: Journal Article
• Language: English
• Published: Tsukuba Japanese Society for Food Science and Technology 2023; The Japanese Society for Food Science and Technology; Japan Science and Technology Agency
• Subjects: Abnormalities; Atrophy; Barley; Blood; Carbohydrates; Cisplatin; Creatinine; Damage; Degeneration; Dehydrogenase; Dehydrogenases; Glutathione; Hexokinase; Kidneys; L-Lactate dehydrogenase; Lactate dehydrogenase; Malate dehydrogenase; Mitochondria; nephrotoxicity; Oxidation; Oxidative stress; polyphenol extract from highland barley; Renal tubules; Superoxide dismutase; Toxicity; Urea

The aim of this study was to investigate the protective effect of polyphenol extract from Highland barley (HBPE) on cisplatin (CDDP)-induced oxidative damage and mitochondrial damage in rat kidney. The experimental rats were divided into control group, CDDP group, HBPE (600 mg/kg) group, CDDP+HBPE (...