Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen

• Published in: Genomics (San Diego, Calif.) Vol. 84; no. 1; pp. 147 - 156
• Main Authors: Yvonne Olsson, A, Lilja, Hans, Lundwall, Åke
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.07.2004; Elsevier
• Subjects: Adenocarcinoma - genetics; Animals; Base Sequence; Basic Medicine; Biological and medical sciences; Classification; Duplication; Evolution, Molecular; Fundamental and applied biological sciences. Psychology; Gene Dosage; Gene Expression Regulation, Neoplastic - genetics; Genes. Genome; Genetics of eukaryotes. Biological and molecular evolution; Genome; Humans; Kallikreins - genetics; Locus; Läkemedelskemi; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinal Chemistry; Medicinska och farmaceutiska grundvetenskaper; Mice; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Paralogs; Phylogeny; Prostate-specific antigen; Prostate-Specific Antigen - genetics; Prostatic Neoplasms - genetics; Rat; Rats; Paralogs; Rat; Duplication; ARE; Prostate-specific antigen; Genome; Locus; hK2; PSA; Serine endopeptidases; Enzyme; Genomics; Identification; Prostate specific antigen; Peptidases; Molecular evolution; Tissue kallikrein; Gene; Hydrolases

In a previous study we demonstrated that repeated duplications of the tissue kallikrein gene ( Klk1) had resulted in 24 paralogs in mouse. Here we demonstrate a different evolution of rat glandular kallikrein genes. Repeated duplications of an ≈30-kb region, encompassing Klk1, Klk15, and Klk2-ps, re...