Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen

In a previous study we demonstrated that repeated duplications of the tissue kallikrein gene ( Klk1) had resulted in 24 paralogs in mouse. Here we demonstrate a different evolution of rat glandular kallikrein genes. Repeated duplications of an ≈30-kb region, encompassing Klk1, Klk15, and Klk2-ps, re...

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Published inGenomics (San Diego, Calif.) Vol. 84; no. 1; pp. 147 - 156
Main Authors Yvonne Olsson, A, Lilja, Hans, Lundwall, Åke
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 01.07.2004
Elsevier
Subjects
Adenocarcinoma - genetics
Animals
Base Sequence
Basic Medicine
Biological and medical sciences
Classification
Duplication
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Gene Dosage
Gene Expression Regulation, Neoplastic - genetics
Genes. Genome
Genetics of eukaryotes. Biological and molecular evolution
Genome
Humans
Kallikreins - genetics
Locus
Läkemedelskemi
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinal Chemistry
Medicinska och farmaceutiska grundvetenskaper
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Paralogs
Phylogeny
Prostate-specific antigen
Prostate-Specific Antigen - genetics
Prostatic Neoplasms - genetics
Rat
Rats
Paralogs
Rat
Duplication
ARE
Prostate-specific antigen
Genome
Locus
hK2
PSA
Serine endopeptidases
Enzyme
Genomics
Identification
Prostate specific antigen
Peptidases
Molecular evolution
Tissue kallikrein
Gene
Hydrolases
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Abstract In a previous study we demonstrated that repeated duplications of the tissue kallikrein gene ( Klk1) had resulted in 24 paralogs in mouse. Here we demonstrate a different evolution of rat glandular kallikrein genes. Repeated duplications of an ≈30-kb region, encompassing Klk1, Klk15, and Klk2-ps, resulted in 10 copies of each gene, but only the Klk1 paralogs are functional. The number of genes varies also between nonrodent mammals, e.g., there are probably no paralogs to KLK1 in cow and pig, whereas horse could have up to 5. In the dog, the gene encoding the prostatic arginine esterase was identified as an ortholog to the progenitor of the PSA and hK2 genes, and it carries the same conserved androgen-responsive elements directing prostate transcription as these genes. This is highly interesting with respect to animal models of benign prostate hyperplasia and prostate adenocarcinoma—diseases that have been described only in humans and dogs.
AbstractList In a previous study we demonstrated that repeated duplications of the tissue kallikrein gene (Klk1) had resulted in 24 paralogs in mouse. Here we demonstrate a different evolution of rat glandular kallikrein genes. Repeated duplications of an approximately 30-kb region, encompassing Klk1, Klk15, and Klk2-ps, resulted in 10 copies of each gene, but only the Klk1 paralogs are functional. The number of genes varies also between nonrodent mammals, e.g., there are probably no paralogs to KLK1 in cow and pig, whereas horse could have up to 5. In the dog, the gene encoding the prostatic arginine esterase was identified as an ortholog to the progenitor of the PSA and hK2 genes, and it carries the same conserved androgen-responsive elements directing prostate transcription as these genes. This is highly interesting with respect to animal models of benign prostate hyperplasia and prostate adenocarcinoma--diseases that have been described only in humans and dogs.
In a previous study we demonstrated that repeated duplications of the tissue kallikrein gene (Klk1) had resulted in 24 paralogs in mouse. Here we demonstrate a different evolution of rat glandular kallikrein genes. Repeated duplications of an 30-kb region, encompassing Klk1, Klk15, and Klk2-ps, resulted in 10 copies of each gene, but only the Klk1 paralogs are functional. The number of genes varies also between nonrodent mammals, e.g., there are probably no paralogs to KLK1 in cow and pig, whereas horse could have up to 5. In the dog, the gene encoding the prostatic arginine esterase was identified as an ortholog to the progenitor of the PSA and hK2 genes, and it carries the same conserved androgen-responsive elements directing prostate transcription as these genes. This is highly interesting with respect to animal models of benign prostate hyperplasia and prostate adenocarcinoma-diseases that have been described only in humans and dogs.
In a previous study we demonstrated that repeated duplications of the tissue kallikrein gene ( Klk1) had resulted in 24 paralogs in mouse. Here we demonstrate a different evolution of rat glandular kallikrein genes. Repeated duplications of an ≈30-kb region, encompassing Klk1, Klk15, and Klk2-ps, resulted in 10 copies of each gene, but only the Klk1 paralogs are functional. The number of genes varies also between nonrodent mammals, e.g., there are probably no paralogs to KLK1 in cow and pig, whereas horse could have up to 5. In the dog, the gene encoding the prostatic arginine esterase was identified as an ortholog to the progenitor of the PSA and hK2 genes, and it carries the same conserved androgen-responsive elements directing prostate transcription as these genes. This is highly interesting with respect to animal models of benign prostate hyperplasia and prostate adenocarcinoma—diseases that have been described only in humans and dogs.
Author Yvonne Olsson, A
Lundwall, Åke
Lilja, Hans
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Issue 1
Keywords Paralogs
Rat
Duplication
ARE
Prostate-specific antigen
Genome
Locus
hK2
PSA
Serine endopeptidases
Enzyme
Genomics
Identification
Prostate specific antigen
Peptidases
Molecular evolution
Tissue kallikrein
Gene
Hydrolases
Language English
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Snippet In a previous study we demonstrated that repeated duplications of the tissue kallikrein gene ( Klk1) had resulted in 24 paralogs in mouse. Here we demonstrate...
In a previous study we demonstrated that repeated duplications of the tissue kallikrein gene (Klk1) had resulted in 24 paralogs in mouse. Here we demonstrate a...
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SubjectTerms Adenocarcinoma - genetics
Animals
Base Sequence
Basic Medicine
Biological and medical sciences
Classification
Duplication
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Gene Dosage
Gene Expression Regulation, Neoplastic - genetics
Genes. Genome
Genetics of eukaryotes. Biological and molecular evolution
Genome
Humans
Kallikreins - genetics
Locus
Läkemedelskemi
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinal Chemistry
Medicinska och farmaceutiska grundvetenskaper
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Paralogs
Phylogeny
Prostate-specific antigen
Prostate-Specific Antigen - genetics
Prostatic Neoplasms - genetics
Rat
Rats
Title Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen
URI https://dx.doi.org/10.1016/j.ygeno.2004.01.009
https://www.ncbi.nlm.nih.gov/pubmed/15203212
https://search.proquest.com/docview/18060110
https://search.proquest.com/docview/66638190
https://lup.lub.lu.se/record/124104
Volume 84
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