Animal models of diabetes mellitus

• Published in: Diabetic medicine Vol. 22; no. 4; pp. 359 - 370
• Main Authors: Rees, D. A., Alcolado, J. C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.04.2005; Blackwell
• Subjects: Animals; Animals, Genetically Modified; Biological and medical sciences; Diabetes Mellitus, Experimental - etiology; Diabetes Mellitus, Type 1 - etiology; Diabetes Mellitus, Type 2 - etiology; Diabetes. Impaired glucose tolerance; Disease Models, Animal; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Ethics, Research; Etiopathogenesis. Screening. Investigations. Target tissue resistance; experimental diabetes; Female; Gene Targeting - methods; Medical sciences; Mice; mouse; Obesity - complications; Pregnancy; Pregnancy in Diabetics - etiology; rat; Rats; rodent; transgenics; Endocrinopathy; Animal model; Vertebrata; Mammalia; Rat; Mouse; experimental diabetes; Animal; Diabetes mellitus; transgenics; Rodentia; rodent
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1111/j.1464-5491.2005.01499.x

Animal models have been used extensively in diabetes research. Early studies used pancreatectomised dogs to confirm the central role of the pancreas in glucose homeostasis, culminating in the discovery and purification of insulin. Today, animal experimentation is contentious and subject to legal and...