MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients

• Published in: Histopathology Vol. 55; no. 3; pp. 321 - 331
• Main Authors: Caramori, Gaetano, Casolari, Paolo, Di Gregorio, Carmela, Saetta, Marina, Baraldo, Simonetta, Boschetto, Piera, Ito, Kazuhiro, Fabbri, Leonardo M, Barnes, Peter J, Adcock, Ian M, Cavallesco, Giorgio, Chung, Kian F, Papi, Alberto
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2009; Blackwell
• Subjects: Aged; Alcian Blue; Biological and medical sciences; Bronchi - metabolism; Bronchi - pathology; chronic bronchitis; Chronic obstructive pulmonary disease, asthma; COPD; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; MUC5AC; MUC5B; Mucin 5AC - metabolism; Mucin-5B - metabolism; Mucins - metabolism; mucus; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Pneumology; Pulmonary Disease, Chronic Obstructive - etiology; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - pathology; Pulmonary Disease, Chronic Obstructive - physiopathology; Respiratory Function Tests; Respiratory Mucosa - metabolism; Smoking - adverse effects; Staining and Labeling; submucosal bronchial glands; Human; Lung disease; Respiratory disease; Mucin 5AC; MUCSAC; Mucus; Bronchial gland; MUC5B; submucosal bronchial glands; Anatomic pathology; Chronic; Bronchus disease; Submucosa; Bronchitis; Chronic obstructive pulmonary disease; chronic bronchitis; Obstructive pulmonary disease; COPD

Aims:  Mucus expectoration is a common feature of chronic obstructive pulmonary disease (COPD). MUC5AC and MUC5B, the major mucins, are released predominantly from submucosal glands in the central airways. The aim was to investigate gland size and MUC5AC and MUC5B expression in bronchial rings from...