The interplay of histone modifications - writers that read

• Published in: EMBO reports Vol. 16; no. 11; pp. 1467 - 1481
• Main Authors: Zhang, Tianyi, Cooper, Sarah, Brockdorff, Neil
• Format: Journal Article
• Language: English
• Published: London Blackwell Publishing Ltd 01.11.2015; Nature Publishing Group UK; Springer Nature B.V; John Wiley & Sons, Ltd
• Subjects: Animals; Cell division; Chromatin; Chromatin - chemistry; Chromatin - genetics; Chromatin - physiology; EMBO09; EMBO31; EMBO44; Gene expression; Histone Code; histone modifications; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; Histones - genetics; Histones - metabolism; Humans; Methylation; Mutation; Myeloid-Lymphoid Leukemia Protein - genetics; Myeloid-Lymphoid Leukemia Protein - metabolism; Polycomb; Polycomb-Group Proteins - genetics; Polycomb-Group Proteins - metabolism; Protein Processing, Post-Translational; Review; Reviews; Transcription, Genetic; Trithorax; Trithorax; Polycomb; histone modifications; chromatin

Histones are subject to a vast array of posttranslational modifications including acetylation, methylation, phosphorylation, and ubiquitylation. The writers of these modifications play important roles in normal development and their mutation or misregulation is linked with both genetic disorders and...