The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation

• Published in: EMBO reports Vol. 22; no. 12; pp. e52764 - n/a
• Main Authors: El Kharraz, Sarah, Dubois, Vanessa, van Royen, Martin E, Houtsmuller, Adriaan B, Pavlova, Ekatarina, Atanassova, Nina, Nguyen, Tien, Voet, Arnout, Eerlings, Roy, Handle, Florian, Prekovic, Stefan, Smeets, Elien, Moris, Lisa, Devlies, Wout, Ohlsson, Claes, Poutanen, Matti, Verstrepen, Kevin J, Carmeliet, Geert, Launonen, Kaisa-Mari, Helminen, Laura, Palvimo, Jorma J, Libert, Claude, Vanderschueren, Dirk, Helsen, Christine, Claessens, Frank
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.12.2021; Blackwell Publishing Ltd; John Wiley and Sons Inc
• Subjects: androgen receptor; Androgen receptors; Androgens; Androstenedione; Animals; Binding sites; Binding Sites - genetics; Biochemistry & Molecular Biology; Cell and Molecular Biology; Cell Biology; Cell- och molekylärbiologi; Chromatin; chromatin binding; Deoxyribonucleic acid; Dimerization; Dimers; Disruption; DNA; domain; EMBO09; estrogen; Gene regulation; insensitivity syndrome; knockout; ligand-binding; Ligands; ligand‐binding domain; Male; mass; Mice; Mutation; Nuclear transport; Phenotypes; protein-protein interactions; Receptors; Receptors, Androgen - chemistry; Receptors, Androgen - genetics; Receptors, Androgen - metabolism; Regulatory sequences; response element; reveals; roles; Sex; Sex glands; Spermatogenesis; structural basis; Testosterone; Therapeutic targets; Transcription activation; Transcriptional Activation; Transcriptomes; Translocation; dimerization; androgen receptor; chromatin binding; ligand-binding domain; transcriptional activation

Whereas dimerization of the DNA-binding domain of the androgen receptor (AR) plays an evident role in recognizing bipartite response elements, the contribution of the dimerization of the ligand-binding domain (LBD) to the correct functioning of the AR remains unclear. Here, we describe a mouse model...